Polymorphism of the Transferrin Gene in Eye Diseases: Keratoconus and Fuchs Endothelial Corneal Dystrophy
Table 4
Distribution of genotypes and alleles of the g.3296G>A, g.3481A>G, and c.–2G>A polymorphisms of the TF gene and odds ratio (OR) with 95% confidence interval (95% CI) in patients with Fuchs endothelial corneal dystrophy (FECD) and controls.
Polymorphisms Genotype/allele
Controls ()
FECD ()
Crude OR (95% CI)
P
Adjusted OR (95% CI)
P
Number
Frequency
Number
Frequency
g.3296G>A
G/G
103
0.45
50
0.38
0.75 (0.49–1.17)
0.205
0.82 (0.50–1.34)
0.420
G/A
115
0.50
71
0.55
1.19 (0.77–1.84)
0.424
1.11 (0.68–1.82)
0.666
A/A
10
0.04
9
0.07
1.61 (0.64–4.08)
0.312
1.58 (0.52–4.79)
0.418
;
G
320
0.70
171
0.66
0.78 (0.54–1.12)
0.173
0.82 (0.54–1.25)
0.356
A
134
0.30
89
0.34
1.33 (0.92–1.92)
0.132
1.25 (0.82–1.91)
0.302
g.3481A>G
A/A
62
0.27
35
0.27
0.99 (0.61–1.60)
0.956
0.88 (0.51–1.53)
0.661
A/G
132
0.58
71
0.55
0.88 (0.57–1.35)
0.547
1.02 (0.62–1.66)
0.902
G/G
34
0.15
24
0.18
1.29 (0.73–2.29)
0.382
1.15 (0.60–2.18)
0.676
;
A
256
0.56
141
0.54
0.91 (0.66–1.27)
0.592
0.90 (0.63–1.31)
0.592
G
200
0.44
119
0.46
1.09 (0.79–1.53)
0.592
1.11 (0.77–1.60)
0.592
c.–2G>A
G/G
61
0.27
35
0.27
0.99 (0.61–1.59)
0.957
0.87 (0.52–1.44)
0.596
G/A
128
0.56
71
0.55
0.94 (0.61–1.45)
0.780
0.99 (0.60–1.61)
0.958
A/A
39
0.17
24
0.18
1.09 (0.63–1.92)
0.746
1.15 (0.60–2.18)
0.676
;
G
250
0.55
141
0.54
0.99 (0.72–1.38)
0.966
0.95 (0.66–1.38)
0.799
A
206
0.45
119
0.46
1.03 (0.74–1.42)
0.870
1.09 (0.75–1.57)
0.658
aOR adjusted for cooccurrence of visual impairment, heart and vascular diseases, age, and family history for FECD.