Table 3: Performance of PLS-regression classifiers for independent validation dataset.

Intrinsic subtypeBasal-likeHER2-enrichedLuminal-ALuminal-BNormal breast-like

Number of samples979416512156
PLS-regression
 Number of gene component21221
-variance explained 71.1%25.5%79.9%61.7%38.1%
-variance explained56.9%41.6%34.5%30.9%18.1%
Binary LR
 Adjusted -square0.86 0.66 0.730.610.39
 AUC0.980.950.950.930.89
 Accuracy96.6%90.7%88.2%86.2%90.5%
 Sensitivity85.6%68.1%81.8%63.6%23.2%
 Specificity99.1%95.5%91.1%92.8%98.3%

PLS: partial least square, LR: logistic regression, AUC: area under the curve.