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BioMed Research International
Volume 2013 (2013), Article ID 252158, 12 pages
Review Article

Therapeutic Approach in the Improvement of Endothelial Dysfunction: The Current State of the Art

1Department of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, P.O. Box 38, 11129 Belgrade, Serbia
2Cardiology Clinic, Clinical Center of Serbia, Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia

Received 24 May 2012; Accepted 30 November 2012

Academic Editor: Paul Higgins

Copyright © 2013 Miroslav Radenković et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The endothelium has a central role in the regulation of blood flow through continuous modulation of vascular tone. This is primarily accomplished by balanced release of endothelial relaxing and contractile factors. The healthy endothelial cells are essential for maintenance of vascular homeostasis involving antioxidant, anti-inflammatory, pro-fibrinolytic, anti-adhesive, or anticoagulant effects. Oppositely, endothelial dysfunction is primarily characterized by impaired regulation of vascular tone as a result of reduced endothelial nitric oxide (NO) synthase activity, lack of cofactors for NO synthesis, attenuated NO release, or increased NO degradation. So far, the pharmacological approach in improving/reversal of endothelial dysfunction was shown to be beneficial in clinical trials that have investigated actions of different cardiovascular drugs. The aim of this paper was to summarize some of the latest clinical findings related to therapeutic possibilities for improving endothelial dysfunction in different pathological conditions. In the majority of presented clinical investigations, the assessment of improvement or reversal of endothelial dysfunction was performed through the flow-mediated dilatation measurement, and in some of those endothelial progenitor cells’ count was used for the same purpose. Still, given the fast and continuous development of this field, the evidence acquisition included the MEDLINE data base screening and the selection of articles published between 2010 and 2012.