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BioMed Research International
Volume 2013, Article ID 254954, 13 pages
Review Article

Genetics of Alzheimer’s Disease

1401 WIDB, Department of Biology, Brigham Young University, Provo, UT 84602, USA
2500 W. Chipeta Way, ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, USA

Received 16 April 2013; Revised 8 July 2013; Accepted 8 July 2013

Academic Editor: Mikko Hiltunen

Copyright © 2013 Perry G. Ridge et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Alzheimer’s disease is the most common form of dementia and is the only top 10 cause of death in the United States that lacks disease-altering treatments. It is a complex disorder with environmental and genetic components. There are two major types of Alzheimer’s disease, early onset and the more common late onset. The genetics of early-onset Alzheimer’s disease are largely understood with variants in three different genes leading to disease. In contrast, while several common alleles associated with late-onset Alzheimer’s disease, including APOE, have been identified using association studies, the genetics of late-onset Alzheimer’s disease are not fully understood. Here we review the known genetics of early- and late-onset Alzheimer’s disease.