Research Article

The Steady-State Serum Concentration of Genistein Aglycone Is Affected by Formulation: A Bioequivalence Study of Bone Products

Table 2

The maximal plasma concentration ( ), time to maximal plasma concentration ( ), areas under curve (AUC) and half-life ( ) after steady administration of the medical food indicated for osteopenia/osteoporosis, the Squadrito study formulation, and the OTC bone supplement.

Study parametersMedical foodSquadrito study formulationOTC bone supplement

(hrs)226
(ng/mL ± StDev)188.4 ± 2.5187.1 ± 3.5153.3 ± 3.5
AUC (ng·hr/mL)9221 ± 4139818 ± 13706474 ± 287
(hrs ± StDev)18.0 ± 6.920.9 ± 4.98.3 ± 1.9