Pharmacokinetics and Bioequivalence Evaluation of Cyclobenzaprine Tablets

Table 1

Pharmacokinetic parameters related to absorption and 90% confidence intervals for 𝐶_max and AUC after single-dose oral administration of one tablet (10 mg of cyclobenzaprine) of reference and test products to 23 healthy volunteers.

	Test; (average ± SD)	Reference; (average ± SD)	90% CI
𝐶max (ng/mL)	7.2±2.5	7.0±2.2	93–112%
AUC (ng*h/mL)	201.6±95.5	199.4±93.7	93–111%
𝑇max (h)	4.6±1.3	4.5±1.3

AUC: area under concentration—time curve; 𝐶_max: peak drug concentration; 𝑇_max: time to reach 𝐶_max; SD: standard deviation; 90% CI: 90% confidence interval.