FOXP3⁺ T Regulatory Cell Modifications in Inflammatory Bowel Disease Patients Treated with Anti-TNF𝜶 Agents

Table 3

Lamina propria (LP) FOXP3⁺ cells*.

Subjects (𝑛)	Mean LP FOXP3^+ cell count before anti-TNFα; (T0)	SD	Mean LP FOXP3^+ cell count after anti-TNFα; (T1)	SD	𝑃 values; T0 versus T1^∧	𝑃 values; T0 versus controls^#	𝑃 values; T1 versus controls^#
All IBD (15)	4.03	3.92	5.69	7.04	0.26	0.0015	0.0077
Crohn’s disease (12)	4.64	4.02	6.97	7.36	0.19	0.0022	0.0076
Ulcerative colitis (3)	1.59	2.75	0.59	0.52	0.64	0.43	0.002
Controls (8)	0.038	0.1

∗Count/high power field.
∧By 𝑡 test for paired samples.
^#By 𝑡 test for independent samples.
IBD: inflammatory bowel disease; TNF: tumor necrosis factor; SD: standard deviation.