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BioMed Research International
Volume 2013 (2013), Article ID 292865, 5 pages
http://dx.doi.org/10.1155/2013/292865
Clinical Study

Efficacy of Triptolide for Children with Moderately Severe Henoch-Schönlein Purpura Nephritis Presenting with Nephrotic Range Proteinuria: A Prospective and Controlled Study in China

1Department of Nephrology, The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China
2Department of Pediatrics, The Second People’s Hospital of Linhai, Linhai, Zhejiang 317016, China

Received 10 October 2013; Accepted 2 December 2013

Academic Editor: Masayuki Iyoda

Copyright © 2013 Li Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Shenoy, M. G. Bradbury, M. A. Lewis, and N. J. A. Webb, “Outcome of Henoch-Schönlein purpura nephritis treated with long-term immunosuppression,” Pediatric Nephrology, vol. 22, no. 10, pp. 1717–1722, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Bogdanović, “Henoch-Schönlein purpura nephritis in children: risk factors, prevention and treatment,” Acta Paediatrica, vol. 98, no. 12, pp. 1882–1889, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. F. Assadi, “Childhood Henoch-Schonlein nephritis: a multivariate analysis of clinical features and renal morphology at disease onset,” Iranian Journal of Kidney Diseases, vol. 3, no. 1, pp. 17–21, 2009. View at Google Scholar · View at Scopus
  4. Y. Kawasaki, J. Suzuki, R. Nozawa, S. Suzuki, and H. Suzuki, “Efficacy of methylprednisolone and urokinase pulse therapy for severe Henoch-Schönlein nephritis,” Pediatrics, vol. 111, no. 4, pp. 785–789, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. P. Tarshish, J. Bernstein, and C. M. Edelmann Jr., “Henoch-Schönlein purpura nephritis: course of disease and efficacy of cyclophosphamide,” Pediatric Nephrology, vol. 19, no. 1, pp. 51–56, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Kawasaki, J. Suzuki, and H. Suzuki, “Efficacy of methylprednisolone and urokinase pulse therapy combined with or without cyclophosphamide in severe Henoch-Schoenlein nephritis: a clinical and histopathological study,” Nephrology Dialysis Transplantation, vol. 19, no. 4, pp. 858–864, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Ronkainen, H. Autio-Harmainen, and M. Nuutinen, “Cyclosporin A for the treatment of severe Henoch-Schönlein glomerulonephritis,” Pediatric Nephrology, vol. 18, no. 11, pp. 1138–1142, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. X. Tao and P. E. Lipsky, “The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook F,” Rheumatic Disease Clinics of North America, vol. 26, no. 1, pp. 29–50, 2000. View at Google Scholar · View at Scopus
  9. X. Jiang, “Clinical observations on the use of the Chinese herb Tripterygium wilfordii Hook for the treatment of nephrotic syndrome,” Pediatric Nephrology, vol. 8, no. 3, pp. 343–344, 1994. View at Publisher · View at Google Scholar · View at Scopus
  10. Y.-Z. Chen, Q. Gao, X.-Z. Zhao et al., “Meta-analysis of tripterygium wilfordii hook F in the immunosuppressive treatment of IgA nephropathy,” Internal Medicine, vol. 49, no. 19, pp. 2049–2055, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. R. Counahan, M. H. Winterborn, R. H. R. White et al., “Prognosis of Henoch Schonlein nephritis in children,” British Medical Journal, vol. 2, no. 6078, pp. 11–14, 1977. View at Google Scholar · View at Scopus
  12. W. Wang, Y. Xia, J. Mao et al., “Treatment of tacrolimus or cyclosporine A in children with idiopathic nephrotic syndrome,” Pediatric Nephrology, vol. 27, pp. 2073–2079, 2012. View at Publisher · View at Google Scholar
  13. Y. Kawasaki, “The pathogenesis and treatment of pediatric Henoch-Schönlein purpura nephritis,” Clinical and Experimental Nephrology, vol. 15, no. 5, pp. 648–657, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Du, L. Hou, C. Zhao, M. Han, and Y. Wu, “Treatment of children with Henoch-Schönlein purpura nephritis with mycophenolate mofetil,” Pediatric Nephrology, vol. 27, pp. 765–771, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. P. . Ren, F. Han, L. Chen, Y. Xu, Y. Wang, and J. Chen, “The combination of mycophenolate mofetil with corticosteroids induces remission of Henoch-Schonlein purpura nephritis,” American Journal of Nephrology, vol. 36, pp. 271–277, 2012. View at Publisher · View at Google Scholar
  16. J. M. Park, S. C. Won, J. I. Shin, H. Yim, and K. S. Pai, “Cyclosporin A therapy for Henoch-Schönlein nephritis with nephrotic-range proteinuria,” Pediatric Nephrology, vol. 26, no. 3, pp. 411–417, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. O. Jauhola, J. Ronkainen, H. Autio-Harmainen et al., “Cyclosporine A versus methylprednisolone for Henoch-Schönlein nephritis: a randomized trial,” Pediatric Nephrology, vol. 26, no. 12, pp. 2159–2166, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. Kidney Disease: Improving Global Outcomes (KDIGO) Glomerulonephritis Work Group, “KDIGO Clinical Practice Guideline for Glomerulonephritis,” Kidney International, supplement 2, pp. 139–274, 2012. View at Google Scholar
  19. G. Xu, W. Tu, D. Jiang, and C. Xu, “Tripterygium wilfordii Hook F treatment for idiopathic refractory nephrotic syndrome in adults: a meta-analysis,” Nephron, vol. 111, no. 4, pp. c223–c228, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Xia, J. Mao, Y. Chen et al., “Clinical outcomes in children with Henoch-SchÖnlein purpura nephritis grade IIIa or IIIb,” Pediatric Nephrology, vol. 26, no. 7, pp. 1083–1088, 2011. View at Publisher · View at Google Scholar · View at Scopus