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BioMed Research International
Volume 2013 (2013), Article ID 294172, 6 pages
http://dx.doi.org/10.1155/2013/294172
Research Article

Evaluation of the Toxicity of Pradosia huberi Extract during the Preimplantation in Wistar Rats

1Biotechnology Center, Federal University of Paraíba, P.O. Box 5009, 58051-970 João Pessoa, PB, Brazil
2Department of Pharmaceutical Sciences, Federal University of Paraíba, P.O. Box 5009, 58051-970 João Pessoa, PB, Brazil
3Department of Pathology and Physiology, Federal University of Paraíba, P.O. Box 5009, 58051-970 João Pessoa, PB, Brazil

Received 24 July 2012; Accepted 12 September 2012

Academic Editor: José Carlos Tavares Carvalho

Copyright © 2013 Aldeíde de Oliveira Batista Rocha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The treatment during the embryonic preimplantation phase of Wistar rats with the Pradosia huberi extract did not interfere with the water and feed consumption, as well as upon the body-weight gain. However, it has expressed a decrease of the uterine implant number, followed by the preimplantation losses at all applied doses (1.22, 6.1, and 30.5 mg/kg), and the number of embryonic resorptions in the two highest doses (6.1 and 30.5 mg/kg). After the organ weighing (hypophysis, ovaries, and uterus), only the relative weight of the hypophysis was raised at the different doses (1.22, 6.1, and 30.5 mg/kg). It was concluded that the hydroalcoholic extract of Pradosia huberi compromises the reproductive ability during the embryonic preimplantation phase, suggesting a possible toxic effect upon the reproductive system of Wistar rats.