Albumin Reduces Paracentesis-Induced Circulatory Dysfunction and Reduces Death and Renal Impairment among Patients with Cirrhosis and Infection: A Systematic Review and Meta-Analysis

Table 1

Study design, patient characteristics and selection criteria.

Study	Design; year of study; country	Number of participants	Mean age	Male %	Selection criteria
Abdel-Khalek and Arif 2010 [19]	Randomized trial; Apr 2008 to Feb 2009; Egypt.	135; 68 albumin; 67 hydroxyethyl starch.	47	79	Patients with cirrhosis and tense ascites which were unresponsive to low-sodium diet and diuretic therapy.
Altman et al. 1998 [20]	Randomized trial; unclear dates; France.	65; 33 albumin; 27 hydroxyethyl starch.	56	73	Patients with cirrhosis and tense ascites.
Choi et al. 2002 [21]	Randomized trial; Jun 1998 to Feb 2001; Korea.	40; 21 albumin; 19 no albumin.	56	78	Patients with cirrhosis and spontaneous bacterial peritonitis.
Fassio et al. 1992 [22]	Randomized trial; Apr 1988 to Mar 1990; Argentina.	40; albumin 21; dextran-70 20.	54	76	Patients with cirrhosis and tense ascites.
Garcia-Compean; et al. 1993 [23]	Randomized trial; unclear dates; Mexico.	35; 17 albumin; 18 no albumin.	56	58	Patients with cirrhosis and tense ascites.
García-Compean; et al. 2002 [24]	Randomized trial; unclear dates; France.	69; albumin 48; dextran-40 48.	59	82	Patients with cirrhosis and tense ascites.
Gines et al. 1988 [2]	Randomized trial; Jul 1985 to Dec 1986, Spain.	105; 52 albumin; 53 no albumin.	57	66	Patients with cirrhosis and tense ascites.
Gines et al. 1996 [25]	Randomized trial; unclear dates, Spain.	289; albumin 97; dextran-70 93; polygeline 99.	58	70	Patients with cirrhosis and tense ascites.
Guevara et al. 2012 [26]	Randomized trial; unclear dates; Spain.	110; 56 albumin and antibiotics; 54 antibiotics.	56	64	Patients with cirrhosis and non-spontaneous bacterial peritonitis infections.
Moreau et al. 2006 [27]	Randomized pilot study; May 2000–Jun 2001; France.	68; 30 albumin; 38 polygeline.	55	82	Patients with cirrhosis and ascites who needed to receive a plasma expander because of paracentesis, renal impairment or marked hyponatraemia.
Nazar et al. 2009 [28]	Randomized trial; unclear dates; Spain.	110; 56 albumin and antibiotics; 54 antibiotics.	NA	NA	Patients with cirrhosis and non-SBP infections.
Planas et al. 1990 [29]	Randomized trial; USA.	88; 43 albumin; 45 dextran-70.	59	63	Patients with cirrhosis and tense ascites treated with paracentesis.
Salemo 1991 [35]	Randomized trial; May 1986–July 1989; Italy.	54; 27 albumin; 27 hemaccel.	54	87	Patients with cirrhosis and refractory ascites.
Sola-Vera et al. 2003 [30]	Randomized trial; Jan 1997–Dec 2000; Spain.	72; 37 albumin; 35 saline.	61	65	Patients with cirrhosis and tense ascites.
Sort et al. 1999 [8]	Randomized trial; Nov 1995–Sept 1997; Spain.	126; 63 cefotaxime and albumin; 63 cefotaxime.	61	64	Patients with cirrhosis and spontaneous bacterial peritonitis.
Xue et al. 2002 [31]	Randomized trial; unclear dates; China.	112; 56 albumin and ceftriaxone; 56 ceftriaxone.	NA	NA	Patients with cirrhosis, ascites and spontaneous bacterial peritonitis.

NA: not available.