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BioMed Research International
Volume 2013 (2013), Article ID 295791, 6 pages
http://dx.doi.org/10.1155/2013/295791
Research Article

The Vitamin D Receptor (VDR) Gene Polymorphisms in Turkish Brain Cancer Patients

1Department of Molecular Medicine, The Institute of Experimental Medicine, İstanbul University, Vakıf Gureba Caddesi, Capa, 34390 Istanbul, Turkey
2Department of Neurosurgery, Cerrahpaşa Faculty of Medicine, İstanbul University, Istanbul, Turkey

Received 25 September 2012; Revised 30 January 2013; Accepted 25 March 2013

Academic Editor: Daniel Prá

Copyright © 2013 Bahar Toptaş et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. It has been stated that brain cancers are an increasingly serious issue in many parts of the world. The aim of our study was to determine a possible relationship between Vitamin D receptor (VDR) gene polymorphisms and the risk of glioma and meningioma. Methods. We investigated the VDR Taq-I and VDR Fok-I gene polymorphisms in 100 brain cancer patients (including 44 meningioma cases and 56 glioma cases) and 122 age-matched healthy control subjects. This study was performed by polymerase chain reaction-based restriction fragment length polymorphism (RF LP). Results. VDR Fok-I ff genotype was significantly increased in meningioma patients (15.9%) compared with controls (2.5%), and carriers of Fok-I ff genotype had a 6.47-fold increased risk for meningioma cases. There was no significant difference between patients and controls for VDR Taq-I genotypes and alleles. Conclusions. We suggest that VDR Fok-I genotypes might affect the development of meningioma.