Mineral and Matrix Changes in Brtl/+ Teeth Provide Insights into Mineralization Mechanisms

Table 1

Micro-CT parameters measured in Brtl/+ and wild type molars at 2 and 6 months.

	Two months				Six months
	First molars		Second molars		First molars		Second molars
	Brtl/+	WT	Brtl/+	WT	Brtl/+	WT	Brtl/+	WT
Crown
BV (D + E) mm^3	0.552±0.0002^a	0.578±0.0003	0.286±0.0003^a	0.342±6.71𝐸−05	0.516±0.0015	0.552±0.0004	0.293±1.44𝐸−05^a	0.332±0.0010
BV (D) mm^3	0.404±0.0001^a	0.435±0.0005	0.200±0.0001^a	0.247±0.0001	0.368±0.0007^a	0.411±0.0002	0.195±1.98𝐸−05^a	0.235±0.0007
BV (E) mm^3	0.148±7.69𝐸−05	0.143±7.58𝐸−05	0.086±5.35𝐸−05^a	0.095±2.99𝐸−05	0.148±0.0002	0.141±2.64𝐸−05	0.098±3.76𝐸−05	0.098±8.37𝐸−05
TMD (D) mg/cm^3	1327±336^a	1266±304	1275±1121	1264.9±271	1337±1080	1306±267	1328±1907	1299±295
TMD (E) mg/cm^3	2024±627	2005±329	1996±382	1995.6±347	2008±1436	2007±244	2002±1346	2006±96
Root
TV mm^3	0.482±0.0005^a	0.544±0.0004	0.243±0.0001^a	0.309±0.0002	0.557±0.0014^a	0.610±0.0005	0.294±0.0008^a	0.355±0.0004
BV mm^3	0.362±0.0007^a	0.460±0.0004	0.111±0.0014^a	0.253±0.0002	0.430±0.0034^a	0.530±0.0004	0.211±0.025^a	0.303±0.0004
BV/TV%	0.752±0.003^a	0.845±0.0002	0.454±0.021^a	0.820±0.0001	0.773±0.086^a	0.870±8.03𝐸−05	0.712±0.018^a	0.853±0.0003
TMD mg/cm^3	1146±416	1162±406	1056±2187^a	1131±704	1177±2709	1227±684	1141±2945	1199.4±644

^a𝑃<0.0125 versus WT of same age and same tooth type, 𝑛=6/genotype.