In Vitro and In Vivo Investigation of the Potential of Amorphous Microporous Silica as a Protein Delivery Vehicle
Figure 1
Surgical procedure, μ-PET scanning, and image analysis. (a) Two holes were drilled in each tibia: one for injecting the protein solution (IN) with (test) or without (control) AMS and the second one for observation of any possible overflow (OUT). Both test and control materials were injected at same time. The holes were sealed using elastomeric material and the incisions were sutured. (b) After suturing the first μ-PET, scanning was started immediately.
