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BioMed Research International
Volume 2013 (2013), Article ID 314091, 10 pages
Research Article

Heparin and Carboxymethylchitosan Metal Nanoparticles: An Evaluation of Their Cytotoxicity

1Dipartimento di Biotecnologie e Scienze della Vita, Università dell'Insubria, 21100 Varese, Italy
2Dipartimento di Scienze Teoriche ed Applicate, Università dell'Insubria, 21100 Varese, Italy
3Dipartimento di Chimica, Materiali e Ingegneria Chimica “G. Natta,” Politecnico di Milano, 20131 Milano, Italy
4Interuniversity Center “The Protein Factory,” Politecnico di Milano, ICRM-CNR Milano and Università dell'Insubria, 20131 Milano, Italy
5Division of Oncology and Hematology, Texas Tech University Health Sciences Center, Lubbock, TX 79409, USA

Received 23 October 2012; Revised 3 January 2013; Accepted 3 January 2013

Academic Editor: Xudong Huang

Copyright © 2013 Adriana Bava et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

We have evaluated by two way ANOVA the cytotoxicity data which are plotted in the text figures.. Differences in cytotoxicity due to exposure time resulted almost always significant. Those due to coating resulted definitely significant only for Co3O4 NPs vs Co3O4@heparinand and Fe3O4 NPs vs Fe3O4@CMCS.

  1. Supplementary Tables