Gsk-3β Inhibitors Mimic the Cardioprotection Mediated by Ischemic Pre- and Postconditioning in Hypertensive Rats

Figure 3

Representative immunoblots of total and phosphorylated forms and summary of densitometry data of P-GSK-3β (a) and phospho-Akt (P-Akt, (b)) level in cytosolic fraction in nonischemic control (NIC), ischemic control (IC), preconditioned (PRE), postconditioned (POS), PRE+W (wortmannin), POS+W, lithium, and IMI treated hearts. Immunoblots of total IC hearts showed less levels of cytosolic P-GSK-3β/GSK-3β and P-Akt/Akt ratios and they were significantly increased by all the interventions. W annulled the effects of PRE and POS. *𝑃<0.05 versus NIC; ^#𝑃<0.05 versus IC; ^ξ𝑃<0.05 versus PRE and POS.

(a)

(b)