Association of Toll-Like Receptor 4 Polymorphisms with Diabetic Foot Ulcers and Application of Artificial Neural Network in DFU Risk Assessment in Type 2 Diabetes Patients

Table 5

Association status of common haplotypes of TLR4 gene with Diabetic Foot Ulcers. Fifteen haplotypes with a frequency of more than 1% was found out of which one haplotype ACATC (𝑃 value = 9.3𝐸−5) was found to be associated with DFU while two haplotypes ATATC (𝑃 value = 0.012) and ATGTT (𝑃 value = 0.008) were found to be protective against DFU in a north Indian population.

Haplotype	Frequency	Case, control frequencies	Chi square	𝑃 value
ACATC	0.280	0.355, 0.204	15.278	9.2789𝐸−5
ACATT	0.136	0.140, 0.130	0.115	0.7351
ACGTC	0.097	0.109, 0.085	0.83	0.3623
ACACC	0.082	0.086, 0.078	0.131	0.7174
ACGCT	0.077	0.065, 0.090	1.202	0.273
ATATC	0.069	0.042, 0.097	6.33	0.0119
GCATC	0.050	0.053, 0.048	0.067	0.7951
GCGTT	0.027	0.020, 0.034	1.013	0.3143
ATGCC	0.025	0.017, 0.033	1.566	0.2108
ACACT	0.024	0.033, 0.015	1.809	0.1786
ATACT	0.022	0.014, 0.030	1.679	0.1951
ACGTT	0.019	0.010, 0.027	2.166	0.1411
ATGTT	0.018	0.003, 0.034	6.88	0.0087
GCATT	0.015	0.008, 0.022	1.961	0.1614
GCACT	0.013	0.012, 0.014	0.06	0.8067