Table 1: Differentially expressed genes in PC-treated hTERT-OA 13A FLS compared with the untreated cells.

Biological processGene
name
Gene IDDiffer.
expre.
(fold)*
Description

Cell proliferationBLMNM_000057−3.64Bloom syndrome
CCNE2AF112857−3.74Cyclin E2
CCNE1AI671049−2.30Cyclin E1
CDC25AAY137580−3.63Cell division cycle 25 homolog A (S. pombe)
CDC25CNM_001790−2.31Cell division cycle 25 homolog C (S. pombe)
CDC2AA749427−3.13Cell division cycle 2, G1 to S and G2 to M
CDC6NM_001254−2.36Cell division cycle 6 homolog (S. cerevisiae)
CDC7NM_003503−2.12Cell division cycle 7 homolog (S. cerevisiae)
CDCA5BE614410−2.41Cell division cycle associated 5
CDCA8BC001651−2.11Cell division cycle associated 8
CDK2AB012305−2.74Cyclin-dependent kinase 2
NCAPHD38553−2.64Non-SMC condensin I complex, subunit H
HELLSNM_018063−2.49Helicase, lymphoid specific
AURKBAB011446−2.43Aurora kinase B
KIF23AW192521−2.41Kinesin family member 23
CLASP2BC029035−2.40Cytoplasmic linker-associated protein 2
NUF2AF326731−2.35NUF2, NDC80 kinetochore complex component, homolog
DSN1NM_024918−2.35DSN1, MIND kinetochore complex component, homolog
SPC24AI469788−2.32SPC24, NDC80 kinetochore complex component, homolog
SPC25AF225416−2.10SPC25, NDC80 kinetochore complex component, homolog
HMGA2AI990940−2.30High mobility group AT-hook 2
LIG1NM_000234−2.25Ligase I, DNA, ATP-dependent
KIFC1BC000712−2.21Kinesin family member C1
BRCA2X95152−2.18Breast cancer 2, early onset
ERCC6LNM_017669−2.17Excision repair cross-complement repair deficiency, comp. group 6 like
SPAG5NM_006461−2.16Sperm-associated antigen 5
NEK2Z25425−2.14Never-in-mitosis-gene-A- (NIMA) related kinase 2
NCAPGNM_022346−2.12Non-SMC condensin I complex, subunit G
ZWINTNM_007057−2.01ZW10 interactor antisense
PARD3BAF428251 3.24 Par-3 partitioning defective 3 homolog B (C. elegans)
11-SepAI333326 2.28 Septin 11

AngiogenesisNRP1AF280547−2.69Neuropilin 1
TEKBF594294−2.58TEK tyrosine kinase, endothelial
ELK3NM_005230−2.42ELK3, ETS-domain protein (SRF accessory protein 2)
EREGNM_001432−1.90Epiregulin
PMLAW291023−1.89Promyelocytic leukemia
COL15A1NM_001855−1.80Collagen, type XV, alpha-1
NRP2AI819729−1.75Neuropilin 2
SPHK1NM_021972−1.72Sphingosine kinase 1
FOXC2NM_005251−1.68Forkhead box C2, mesenchyme forkhead 1 (MFH-1)
SCG2NM_003469−1.66Secretogranin II (chromogranin C)
EDNRANM_001957−1.56Endothelin receptor type A
TGFBR2NM_003242−1.51Transforming growth factor, beta-receptor II (70/80kDa)
ROBO4AA156022−1.51Roundabout homolog 4, magic roundabout (Drosophila)
JAG1AI4578172.42Jagged 1 (Alagille syndrome)
NOTCH4AI3412711.75Notch homolog 4 (Drosophila)
RUNX1D897881.73Runt-related transcription factor 1
EPAS1NM_0014301.67Endothelial PAS domain protein 1

Inflammatory responsePTGS2AY151286−6.09Prostaglandin-endoperoxide synthase 2
SERPINA1AF119873−2.15Serpin peptidase inhibitor, clade A
GPR68AI805006−2.15G protein-coupled receptor 68
BMPR1BAA935461−2.12Bone morphogenetic protein receptor, type IB
EVI1BE466525−2.00Ecotropic viral integration site 1
FOSBC004490−1.92V-fos FBJ murine osteosarcoma viral oncogene homolog
IRAK2AI246590−1.82Interleukin-1 receptor-associated kinase 2
CCL2S69738−1.82Chemokine (C-C motif) ligand 2
CCR1NM_001295−1.60Chemokine (C-C motif) receptor 1
CXCL2M57731−1.66Chemokine (C-X-C motif) ligand 2
SPNBC035510−1.79Sialophorin (leukosialin, CD43)
TLR4AF177765−1.70Toll-like receptor 4
SCG2NM_003469−1.66Secretogranin II (chromogranin C)
FN1AJ276395−1.58Fibronectin 1
KLKB1BE326857−1.52Cytochrome P450, family 4, subfamily V, polypeptide 2
NDST1NM_0015432.05N-Deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
C3NM_0000642.05Complement component 3
SERPINA3NM_0010851.88Serpin peptidase inhibitor, clade A
SBNO2AC0053901.78Strawberry notch homolog 2 (Drosophila)
NFKBIZBE6465731.74Nuclear factor of kappa light polypeptide enhancer in B-cells inhibitor zeta
MASP1NM_0018791.64Mannan-binding lectin serine peptidase 1
STAT5BNM_0124481.59Signal transducer and activator of transcription 5B

Response to painTACR1AA461490−4.39Tachykinin receptor 1
COMTBG149428−2.03Catechol-O-methyltransferase
CACNA1ABC042451−2.00Calcium channel, voltage-dependent, P/Q type, alpha-1A subunit

Response to interleukin-1SRCNM_005417−3.95V-src sarcoma viral oncogene homolog (avian)
IRAK2AI246590−1.82Interleukin-1 receptor-associated kinase 2
PCSK1NM_000439−1.60Proprotein convertase subtilisin/kexin type 1
IL1R1AK026803−1.59Interleukin-1 receptor, type I
GHRNM_000163 1.76 Growth hormone receptor

Cytokine- and chemokine- mediatedEREGNM_001432−1.90Epiregulin
CCL2S69738−1.82Chemokine (C-C motif) ligand 2
LIFRNM_002310−1.77Leukemia inhibitory factor receptor-alpha
RQCD1BC007102−1.76RCD1 required for cell differentiation1 homolog (S. pombe)
LRP8NM_004631−1.73Low-density lipoprotein receptor-related protein 8, apolipoprotein e receptor
CCR1NM_001295−1.60Chemokine (C-C motif) receptor 1
IL1RIAK026803−1.59Interleukin-1 receptor, type I
STAT3BF5089772.01Signal transducer and activator of transcription 3
STAT5BNM_0124481.59Signal transducer and activator of transcription 5B

Interleukin-6 productionBCL10AA994334−2.38B-cell CLL/lymphoma 10
TNFAIP3AI738896−2.07Tumor necrosis factor, alpha-induced protein 3
FOXP3NM_014009−1.92Forkhead box P3
EREGNM_001432−1.90Epiregulin
TOLR4AF177765−1.70Toll-like receptor 4
ADORA2BNM_000676−1.59Adenosine A2b receptor
IL6RNM_0005652.03Interleukin-6 receptor

MiscellaneousPLAUK03226−2.21Plasminogen activator, urokinase
PLAURU08839−1.92Plasminogen activator, urokinase receptor
PLA2G4AM68874−1.51Phospholipase A2, group IVA (cytosolic, calcium dependent)
PTGER4AA897516−1.91Prostaglandin E receptor 4 (subtype EP4)
EGR1AI459194−2.25Early growth response 1
FOSBC004490−1.92V-fos FBJ murine osteosarcoma viral oncogene homolog
FOSL1BG251266−1.95FOS-like antigen 1
THBS1BF0841052.41Thrombospondin 1

Negative number indicates decreased expression (fold) in PC-treated hTERT-OA 13A FLS compared with the untreated cells. Positive number indicates elevated expression (fold) in PC-treated hTERT-OA 13A FLS compared with the untreated cells.