Table 2: Differentially expressed genes in PC-treated hTERT-OA 13A FLS compared to the untreated cells.

Biological processGene name Gene IDDiffer.
Expre.
(fold)*
Description

Muscle tissue developmentIGFBP5AW1575488.57Insulin-like growth factor binding protein 5
CACNB4NM_0007262.73Calcium channel, voltage-dependent, beta-4-subunit
TPM1AI5216182.43Tropomyosin 1 (alpha)
JAG1U612762.02Jagged 1 (Alagille syndrome)
MORF4L2H439761.90Mortality factor 4 like 2
NRG1NM_0139571.88Neuregulin 1
SIRT2BG7227791.86Sirtuin (silent mating type information regulation 2 homolog) 2
NF1D126251.80Neurofibromin 1
OBSL1BF4466881.78Obscurin-like 1
MBNL1AA7322401.73Muscleblind-like (Drosophila)
TPM1NM_0003661.72Tropomyosin 1 (alpha)
CAV2AA1501101.67Caveolin 2
RXRABE6758001.66Retinoid X receptor, alpha
NR2F2AL5542451.63Nuclear receptor subfamily 2, group F, member 2
TCF7L2AV7214301.61Transcription factor 7-like 2 (T-cell specific, HMG-box)
TBX2U28049−4.17T-box 2
ADRB2NM_000024−2.36Adrenergic, beta-2-receptor, surface
SORT1BE742268−1.93Sortilin 1
GJC1NM_005497−1.77Gap junction protein, gamma 1, 45 kDa
CENPFU30872−1.77Centromere protein F, 350/400 ka (mitosin)
BCL2NM_000657−1.71B-cell CLL/lymphoma 2
TBX3U69556−1.71T-box 3
SDC1NM_002997−1.65Syndecan 1
TBX5AW269421−1.54T-box 5
RARBNM_015854−1.51Retinoic acid receptor, beta

Skeletal developmentANXA2D283642.17Annexin A2
VDRAA7722852.11Vitamin D (1,25-dihydroxyvitamin D3) receptor
GNASAI6931431.95GNAS complex locus
ACANNM_0011351.80Aggrecan
COL1A1AI7436211.66Collagen, type I, alpha-1
COL1A2AA6285351.88Collagen, type I, alpha-2
COL11A1NM_0018541.50Collagen, type XI, alpha-1
COL12A1AU1466511.93Collagen, type XII, alpha-1
MSX2D893771.85Msh homeobox 2
GHRNM_0001631.76Growth hormone receptor
MEF2CAL5365171.59Myocyte enhancer factor 2C
THRANM_0032501.57Thyroid hormone receptor, alpha
RUNX2AW4695461.55Runt-related transcription factor 2
CLEC3BNM_0032781.55Exosome component 7
MEF2CN224681.55Myocyte enhancer factor 2C
IGFBP4NM_0015521.54Insulin-like growth factor binding protein 4
PRKRAAA2794621.53Protein kinase, interferon-inducible RNA-dependent activator
TNFRSF11BNM_0025461.50Tumor necrosis factor receptor superfamily, member 11b
BMPR1BAA935461−2.12Bone morphogenetic protein receptor, type IB
ANKHAF274753−1.93Ankylosis, progressive homolog (mouse)
ACVR2ANM_001616−1.89Activin A receptor, type IIA
CYTL1NM_018659−1.83Cytokine-like 1
TBX3U69556−1.71T-box 3 (ulnar mammary syndrome)
SOX9NM_000346−1.71SRY- (sex-determining-region-Y-) box 9
FOXC2NM_005251−1.68Forkhead box C2 (MFH-1, mesenchyme forkhead 1)
KIAA1217BC017424−1.66KIAA1217
MMP9NM_004994−1.61Matrix metallopeptidase 9
TGFBR2NM_003242−1.51Transforming growth factor, beta-receptor II (70/80 kDa)

Collagen biosynthetic processCOL3A1AU146808 1.83 Collagen, type III, alpha-1
COL1A2AA628535 1.88 Collagen, type I, alpha-2
COL1A1AI743621 1.66 Collagen, type I, alpha-1
TRAM2AI986461 1.58 Translocation-associated membrane protein 2
ITGA2N95414−1.74Integrin, alpha-2 (CD49B, alpha-2 subunit of VLA-2 receptor)

Collagen catabolic processMMP3NM_002422 3.18 Matrix metallopeptidase 3 (stromelysin 1, progelatinase)
ADAMTS5BI254089 3.32 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADAMTS14W60649 2.15 ADAM metallopeptidase with thrombospondin type 1 motif, 14
MMP16U79292 1.80 Matrix metallopeptidase 16 (membrane inserted)
MMP9NM_004994−1.61Matrix metallopeptidase 9

Negative number indicates decreased expression (fold) in PC-treated hTERT-OA 13A FLS compared with the untreated cells. Positive number indicates elevated expression (fold) in PC-treated hTERT-OA 13A FLS compared with the untreated cells.