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BioMed Research International
Volume 2013, Article ID 351031, 20 pages
Review Article

Application of Nanoparticles on Diagnosis and Therapy in Gliomas

1Neuroimmunology and Neuro-Oncology Unit, National Institute of Neurology and Neurosurgery, 14269 Mexico City, DF, Mexico
2Excitatory Amino Acids Laboratory, National Institute of Neurology and Neurosurgery, 3877 Mexico City, DF, Mexico

Received 5 January 2013; Accepted 13 March 2013

Academic Editor: Alejandro Sosnik

Copyright © 2013 Norma Y. Hernández-Pedro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Glioblastoma multiforme (GBM) is one of the most deadly diseases that affect humans, and it is characterized by high resistance to chemotherapy and radiotherapy. Its median survival is only fourteen months, and this dramatic prognosis has stilled without changes during the last two decades; consequently GBM remains as an unsolved clinical problem. Therefore, alternative diagnostic and therapeutic approaches are needed for gliomas. Nanoparticles represent an innovative tool in research and therapies in GBM due to their capacity of self-assembly, small size, increased stability, biocompatibility, tumor-specific targeting using antibodies or ligands, encapsulation and delivery of antineoplastic drugs, and increasing the contact surface between cells and nanomaterials. The active targeting of nanoparticles through conjugation with cell surface markers could enhance the efficacy of nanoparticles for delivering several agents into the tumoral area while significantly reducing toxicity in living systems. Nanoparticles can exploit some biological pathways to achieve specific delivery to cellular and intracellular targets, including transport across the blood-brain barrier, which many anticancer drugs cannot bypass. This review addresses the advancements of nanoparticles in drug delivery, imaging, diagnosis, and therapy in gliomas. The mechanisms of action, potential effects, and therapeutic results of these systems and their future applications in GBM are discussed.