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BioMed Research International
Volume 2013, Article ID 351942, 6 pages
Research Article

Relationship between Vitamin D Receptor Gene Polymorphisms and Migraine without Aura in an Iranian Population

1Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
2Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran
3School of Pharmacy and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
4Department of Neurology and Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Received 19 March 2013; Revised 1 June 2013; Accepted 24 June 2013

Academic Editor: Sebastian Straube

Copyright © 2013 Mohammad Motaghi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Inflammation has a key role in migraine pathophysiology. Vitamin D is an effective anti-inflammatory agent. The aim of this study was to investigate the association between migraine and two vitamin D receptor (VDR) polymorphisms (TaqI and FokI) and also the relationship between VDR polymorphisms and headache severity. Methods. In this case-control study we assessed 103 patients with newly diagnosed migraine without aura and 100 healthy subjects. Patients filled headache impact test-6 (HIT-6) as a tool to assess headache severity. Results. Genotype frequencies of VDR were significantly different between control and migraine patients. Heterozygote genotypes (Ff and Tt) were statistically more frequent in the migraine patients than the control subjects both for TaqI gene ( ; OR = 1.81, 95% CI = 1.03–3.18) and FokI gene polymorphisms ( ; OR = 2.91, 95% CI = 1.47–5.77). Also f and t alleles were more frequent in the migraine patients. Total HIT-6 score was significantly different between FokI heterozygote and homozygote patients ( versus , resp., ). Conclusions. In conclusion our results showed that TaqI and FokI gene polymorphisms are associated with migraine without aura in Iranians patients. Also headache severity in FokI heterozygote patients was significantly greater than in the homozygote patients.