Research Article

Comparative Gene Expression Profiling in Human Cumulus Cells according to Ovarian Gonadotropin Treatments

Table 1

List of genes that were significantly upregulated in HP-hMG CCs compared with rFSH CCs.

Gene nameGene titleProbesetsFold changeFDR (%)

PHACTR2Phosphatase and actin regulator 2244774_at2.90
GM2AGM2 ganglioside activator235678_at2.30
LOC654433Homo sapiens, clone IMAGE:4826696, mRNA228425_at2.20
LOC201651Similar to esterase/N-deacetylase (EC 3.5.1.-), 50 K hepatic-rabbit1569582_at2.10
PAX8Transcribed locus, moderately similar to XP_375099.1 hypothetical protein LOC283585 (Homo sapiens)227474_at2.10
NPY1RNeuropeptide Y receptor Y1205440_s_at2.10
GJA5Gap junction protein, alpha 5, 40 kDa (connexin 40)226701_at1.90
FOXG1BForkhead box G1B206018_at1.90
SPP1Secreted phosphoprotein 1209875_s_at1.90.58
NTSNeurotensin206291_at1.80.58
THAP4THAP domain containing 4220417_s_at1.80
SPESP1Sperm equatorial segment protein 1229352_at1.80.58
SEMA6DSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D233882_s_at1.80.58
DOCK8Dedicator of cytokinesis 8225502_at1.80.58
SERPINB2Serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2204614_at1.70.58
PPP1R14CProtein phosphatase 1, regulatory (inhibitor) subunit 14C226907_at1.70
CTIFCBP80/20-dependent translation initiation factor243090_at1.70
SSFA2Sperm-specific antigen 2236207_at1.70
HS3ST1Heparan sulfate (glucosamine) 3-O-sulfotransferase 1205466_s_at1.70
CYP1B1Cytochrome P450, family 1, subfamily B, polypeptide 1202437_s_at1.70
TMEM37Transmembrane protein 371554485_s_at1.60
BBS12Hypothetical protein FLJ35630229603_at1.60
AKR1C2Aldo-keto reductase family 1, member C2211653_x_at1.60.58
MALLBENE protein209373_at1.60
NPY2RNeuropeptide Y receptor Y2210729_at1.60
METTL7BHypothetical protein MGC17301227055_at1.60
RNF128Ring finger protein 128219263_at1.60
ARL4CADP-ribosylation factor-like 7202207_at1.60
PAPPAPregnancy-associated plasma protein A, pappalysin 1240450_at1.60
USP45Ubiquitin-specific protease 45224441_s_at1.60
FOSv-fos FBJ murine osteosarcoma viral oncogene homolog209189_at1.60
PDK4Pyruvate dehydrogenase kinase, isozyme 4225207_at1.60
ZNF718Hypothetical protein FLJ900361553269_at1.60
ARHGAP20Rho GTPase activating protein 20228368_at1.50
FLJ43663CDNA FLJ26188 fis, clone ADG04821238619_at1.50
HOPHomeodomain-only protein211597_s_at1.50
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)209392_at1.52.95
LYZLysozyme (renal amyloidosis)213975_s_at1.51.05
SKAP2src family associated phosphoprotein 2204361_s_at1.50
ABHD12Chromosome 20 open reading frame 22228124_at1.50
RUNX1Runt-related transcription factor 1236114_at1.50
AKR1C1Aldo-keto reductase family 1, member C2216594_x_at1.50
BREBrain and reproductiveorgan-expressed(TNFRSF1A modulator)211566_x_at1.50
SERPINI1Serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1205352_at1.50
RASL11BRAS-like, family 11, member B219142_at1.50