Figure 3: Effect of edaravone on TBI after CCI based on TB staining. (a) Representative core- (upper) and peri-injury (lower) images of TB staining 24 hours after CCI. The region with little or no staining was defined as the injury area. Edaravone ( ) was injected at 0, 3, or 6 hours and vehicle ( ) at 0 hours after CCI. The total (b) or core- and peri-injury (c) areas were semiquantified in each experimental group. Data are expressed as mean ± SEM. Asterisk (*) indicates a significant difference between the groups based on Tukey-Kramer tests.