Meta-Analysis of Cytokine Gene Polymorphisms and Outcome of Heart Transplantation

Table 1

Characteristic of studies which were included in meta-analysis.

Author, year	No. of subjects	Country	Design	Mean age	Percent male	Immunosuppressive agents	HLA	Outcome
Azzawi et al. 2001 [11]	119	United Kingdom	Cohort			Cyclosporine (4–12 mg/kg/day); Azathioprine (1-2 mg/kg/day); Prednisolone (0.1–0.2 mg/kg/day)	Not based on HLA matching	AGR/CGR
Bijlsma et al. 2002 [6]	70	The Netherlands	Cohort					AGR
Plaza et al. 2003 [10]	71	Columbia	Cohort	45.6	83.1	Cyclosporine, prednisolone, and azathioprine	Complete match
Gourley et al. 2004 [8]	92	Pennsylvania	Cohort	52.0	79.0	Cyclosporine, prednisone, and azathioprine/mycophenolate mofetil	87% had >3 mismatch	AGR
McDaniel et al. 2004 [9]	55*	Mississippi	Cohort	—	76.0			AGR
Filippo et al. 2006 [7]	111	Pittsburgh	Cohort	7.5	56.8	Tacrolimus/cyclosporine, and corticosteroid	—	AGR/CGR
Girnita et al. 2008 [12]	322	Washington	Cohort	5.3	57.0	—	—	AGR/CGR

AGR: acute graft rejection; CGR: chronic graft rejection.
∗Authors provided data.