Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2013 (2013), Article ID 389579, 6 pages
Research Article

Relationship between Circulating BAFF Serum Levels with Proliferating Markers in Patients with Multiple Myeloma

1Hematology Department, University Hospital of Heraklion, P.O. Box 1352, Stavrakia, 71110 Heraklion, Greece
2Hematology Laboratory, University Hospital of Heraklion, Stavrakia, 71110 Heraklion, Greece
33rd Department of Internal Medicine, Medical School of Athens, Sotiria Hospital, 11527 Athens, Greece
4Pathology Department, University Hospital of Heraklion, Stavrakia, 71110 Heraklion, Greece
5Hematology Department, Venizelion Hospital of Heraklion, 71409 Heraklion, Greece

Received 6 April 2013; Revised 9 June 2013; Accepted 23 June 2013

Academic Editor: Jerome Moreaux

Copyright © 2013 Michael G. Alexandrakis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In multiple myeloma, there are many factors influencing the growth of the malignant clone in direct and indirect manners. BAFF is a growth factor for myeloma cells. The aim of the study was to measure its circulating levels in 54 pretreatment patients, along with serum levels of other proliferation markers, such as interleukins-6, -10, and -15, CRP, and beta-2 microglobulin, as well as bone marrow plasma cell infiltration and expression of Ki-67 PI, in various stages of the disease and after effective treatment in 28 of them. Serum levels of the previously mentioned factors were measured by ELISA, whereas bone marrow plasma cell infiltration and Ki-67 expression were estimated immunohistochemically. All measured parameters were higher in pretreated myeloma patients compared to healthy population and were also increasing with the progression of the disease. They all also decreased after effective therapy. Furthermore, all pretreatment values correlated to each other. BAFF seems to be an important growth factor for myeloma plasma cells. Measuring its serum levels, along with the previously mentioned cytokines, may provide important information regarding the degree of myeloma cells’ proliferation. Therefore, they all could be used as markers of proliferation and disease activity.