Relationship between Circulating BAFF Serum Levels with Proliferating Markers in Patients with Multiple Myeloma

Table 2

Mean ± SD values of B-cell activating factor (BAFF), interleukin-6, -10, and -15 (IL-6, -10, and -15), C-reactive protein (CRP), beta-2 microglobulin (B2M), Ki-67 proliferation index (Ki-67 PI), and plasma cell infiltration among International Staging System multiple myeloma stages (𝑃<0.004 for B2M, 𝑃<0.001 for the other cases).

	Stage I	Stage II	Stage III
BAFF (pg/mL)	498.5 ± 187.0	813.7 ± 398.3	1365.4 ± 641.5
IL-6 (pg/mL)	3.0 ± 1.2	6.2 ± 3.2	16.7 ± 8.5
IL-10 (pg/mL)	126.1 ± 26.0	150.3 ± 29.6	232.1 ± 91.9
IL-15 (pg/mL)	7.2 ± 1.2	7.7 ± 1.2	13.4 ± 6.4
CRR (mg/dL)	0.6 ± 0.3	0.9 ± 0.6	1.2 ± 0.7
B2M (mg/L)	1.8 ± 0.7	4.1 ± 3.5	7.4 ± 1.6
Ki-67 PI (%)	4.0 ± 2.4	7.1 ± 5.2	16.5 ± 14.6
Infiltration (%)	26.1 ± 10.8	39.4 ± 16.5	55.6 ± 14.6