Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2013, Article ID 390493, 10 pages
http://dx.doi.org/10.1155/2013/390493
Research Article

Dantrolene-Induced Inhibition of Skeletal L-Type Ca2+ Current Requires RyR1 Expression

Division of Cardiology, Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, P-15 8006, B-139, Aurora, CO 80045, USA

Received 20 April 2012; Revised 6 June 2012; Accepted 6 June 2012

Academic Editor: Dobromir Dobrev

Copyright © 2013 R. A. Bannister. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. G. Beam and R. A. Bannister, “Looking for answers to EC coupling's persistent questions,” Journal of General Physiology, vol. 136, no. 1, pp. 7–12, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Nakai, R. T. Dirksen, H. T. Nguyen, I. N. Pessah, K. G. Beam, and P. D. Allen, “Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor,” Nature, vol. 380, no. 6569, pp. 72–75, 1996. View at Publisher · View at Google Scholar · View at Scopus
  3. G. Avila and R. T. Dirksen, “Functional impact of the ryanodine receptor on the skeletal muscle L-type Ca2+ channel,” Journal of General Physiology, vol. 115, no. 4, pp. 467–480, 2000. View at Publisher · View at Google Scholar · View at Scopus
  4. C. A. Ahern, D. C. Sheridan, W. Cheng et al., “Ca2+ current and charge movements in skeletal myotubes promoted by the β-subunit of the dihydropyridine receptor in the absence of ryanodine receptor type 1,” Biophysical Journal, vol. 84, no. 2, pp. 942–959, 2003. View at Google Scholar · View at Scopus
  5. D. C. Sheridan, H. Takekura, C. Franzini-Armstrong, K. G. Beam, P. D. Allen, and C. F. Perez, “Bidirectional signaling between calcium channels of skeletal muscle requires multiple direct and indirect interactions,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 52, pp. 19760–19765, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Nakai, N. Sekiguchi, T. A. Rando, P. D. Allen, and K. G. Beam, “Two regions of the ryanodine receptor involved in coupling with L-type Ca2+ channels,” The Journal of Biological Chemistry, vol. 273, no. 22, pp. 13403–13406, 1998. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Grabner, R. T. Dirksen, N. Suda, and K. G. Beam, “The II-III loop of the skeletal muscle dihydropyridine receptor is responsible for the Bi-directional coupling with the ryanodine receptor,” The Journal of Biological Chemistry, vol. 274, no. 31, pp. 21913–21919, 1999. View at Publisher · View at Google Scholar · View at Scopus
  8. R. Robinson, D. Carpenter, M. A. Shaw, J. Halsall, and P. Hopkins, “Mutations in RYR1 in malignant hypertheraiia and central core disease,” Human Mutation, vol. 27, no. 10, pp. 977–989, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. J. T. Lanner, “Ryanodine receptor physiology and its role in disease,” Advances in Experimental Medicine and Biology, vol. 740, no. 1, pp. 217–234.
  10. N. Monnier, V. Procaccio, P. Stieglitz, and J. Lunardi, “Malignant-hyperthermia susceptibility is associated with a mutation of the α1-subunit of the human dihydropyridine-sensitive L-type voltage- dependent calcium-channel receptor in skeletal muscle,” American Journal of Human Genetics, vol. 60, no. 6, pp. 1316–1325, 1997. View at Google Scholar · View at Scopus
  11. D. Carpenter, C. Ringrose, V. Leo et al., “The role of CACNA1S in predisposition to malignant hyperthermia,” BMC Medical Genetics, vol. 10, article 104, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Pirone, J. Schredelseker, P. Tuluc et al., “Identification and functional characterization of malignant hyperthermia mutation T1354S in the outer pore of the Cavα1S- subunit,” American Journal of Physiology, vol. 299, no. 6, pp. C1345–C1354, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. P. J. Toppin, T. T. Chandy, A. Ghanekar, N. Kraeva, W. S. Beattie, and S. Riazi, “A report of fulminant malignant hyperthermia in a patient with a novel mutation of the CACNA1S gene,” Canadian Journal of Anesthesia, vol. 57, no. 7, pp. 689–693, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. P. M. Hopkins, “Malignant hyperthermia: pharmacology of triggering,” British Journal of Anaesthesia, vol. 107, no. 1, pp. 48–56, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. T. Krause, M. U. Gerbershagen, M. Fiege, R. Weisshorn, and F. Wappler, “Dantrolene—a review of its pharmacology, therapeutic use and new developments,” Anaesthesia, vol. 59, no. 4, pp. 364–373, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. X. Zhao, N. Weisleder, X. Han et al., “Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor,” The Journal of Biological Chemistry, vol. 281, no. 44, pp. 33477–33486, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. X. Zhao, C. K. Min, J. K. Ko et al., “Increased store-operated Ca2+ entry in skeletal muscle with reduced calsequestrin-1 expression,” Biophysical Journal, vol. 99, no. 5, pp. 1556–1564, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Cherednichenko, C. W. Ward, W. Feng et al., “Enhanced excitation-coupled calcium entry in myotubes expressing malignant hyperthermia mutation R163C is attenuated by dantrolene,” Molecular Pharmacology, vol. 73, no. 4, pp. 1203–1212, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. R. A. Bannister, I. N. Pessah, and K. G. Beam, “The skeletal L-type Ca2+ current is a major contributor to excitation-coupled Ca2+ entry (ECCE),” Journal of General Physiology, vol. 133, no. 1, pp. 79–91, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. R. A. Bannister and K. G. Beam, “The cardiac α1C subunit can support excitation-triggered Ca2+ entry in dysgenic and dyspedic myotubes,” Channels, vol. 3, no. 4, pp. 268–273, 2009. View at Google Scholar · View at Scopus
  21. K. G. Beam and C. Franzini-Armstrong, “Functional and structural approaches to the study of excitation-contraction coupling,” Methods in Cell Biology, vol. 52, no. 1, pp. 283–306, 1997. View at Google Scholar · View at Scopus
  22. O. P. Hamill, A. Marty, E. Neher, B. Sakmann, and F. J. Sigworth, “Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches,” Pflugers Archiv, vol. 391, no. 2, pp. 85–100, 1981. View at Google Scholar · View at Scopus
  23. P. A. Pappone, “Voltage-clamp experiments in normal and denervated mammalian skeletal muscle fibres,” Journal of Physiology, vol. 306, no. 1, pp. 377–410, 1980. View at Google Scholar · View at Scopus
  24. C. Paolini, F. Protasi, and C. Franzini-Armstrong, “The relative position of RyR feet and DHPR tetrads in skeletal muscle,” Journal of Molecular Biology, vol. 342, no. 1, pp. 145–153, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. P. Szentesi, C. Collet, S. Sárközi et al., “Effects of dantrolene on steps of excitation-contraction coupling in mammalian skeletal muscle fibers,” Journal of General Physiology, vol. 118, no. 4, pp. 355–375, 2001. View at Publisher · View at Google Scholar · View at Scopus
  26. K. O. Ellis and J. F. Carpenter, “Studies on the mechanism of action of dantrolene sodium—a skeletal muscle relaxant,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 275, no. 1, pp. 83–94, 1972. View at Publisher · View at Google Scholar · View at Scopus
  27. B. L. Prosser, E. O. Hernández-Ochoa, D. B. Zimmer, and M. F. Schneider, “The Qγ component of intra-membrane charge movement is present in mammalian muscle fibres, but suppressed in the absence of S100A1,” Journal of Physiology, vol. 587, no. 18, pp. 4523–4541, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. S. S. Palnitkar, J. R. Mickelson, C. F. Louis, and J. Parness, “Pharmacological distinction between dantrolene and ryanodine binding sites: evidence from normal and malignant hyperthermia-susceptible porcine skeletal muscle,” The Biochemical Journal, vol. 326, no. 3, pp. 847–852, 1997. View at Google Scholar · View at Scopus
  29. J. Parness and S. S. Palnitkar, “Identification of dantrolene binding sites in porcine skeletal muscle sarcoplasmic reticulum,” The Journal of Biological Chemistry, vol. 270, no. 31, pp. 18465–18472, 1995. View at Publisher · View at Google Scholar · View at Scopus
  30. B. R. Fruen, J. R. Mickelson, and C. F. Louis, “Dantrolene inhibition of sarcoplasmic reticulum Ca2+ release by direct and specific action at skeletal muscle ryanodine receptors,” The Journal of Biological Chemistry, vol. 272, no. 43, pp. 26965–26971, 1997. View at Publisher · View at Google Scholar · View at Scopus
  31. T. Ikemoto, T. Hosoya, H. Aoyama, Y. Kihara, M. Suzuki, and M. Endo, “Effects of dantrolene and its derivatives on Ca2+ release from the sarcoplasmic reticulum of mouse skeletal muscle fibres,” British Journal of Pharmacology, vol. 134, no. 4, pp. 729–736, 2001. View at Google Scholar · View at Scopus
  32. E. Buck, I. Zimányi, J. J. Abramson, and I. N. Pessah, “Ryanodine stabilizes multiple conformational states of the skeletal muscle calcium release channel,” The Journal of Biological Chemistry, vol. 267, no. 33, pp. 23560–23567, 1992. View at Google Scholar · View at Scopus
  33. I. Zimányi, E. Buck, J. J. Abramson, M. M. Mack, and I. N. Pessah, “Ryanodine induces persistent inactivation of the Ca2+ release channel from skeletal muscle sarcoplasmic reticulum,” Molecular Pharmacology, vol. 42, no. 6, pp. 1049–1057, 1992. View at Google Scholar · View at Scopus
  34. E. M. Balog and E. M. Gallant, “Modulation of the sarcolemmal L-type current by alteration in SR Ca2+ release,” American Journal of Physiology, vol. 276, no. 1, pp. C128–C135, 1999. View at Google Scholar · View at Scopus
  35. R. A. Bannister and K. G. Beam, “Ryanodine modification of RyR1 retrogradely affects L-type Ca2+ channel gating in skeletal muscle,” Journal of Muscle Research and Cell Motility, vol. 30, no. 5-6, pp. 217–223, 2009. View at Publisher · View at Google Scholar · View at Scopus