Concerted Action of ANP and Dopamine D1-Receptor to Regulate Sodium Homeostasis in Nephrotic Syndrome
Table 1
Body weight, metabolic balance, and renal function in control and PAN-NS rats, seven and fourteen days after injection.
Day 7
Day 14
Control
PAN-NS
Control
PAN-NS
Body weight (g)
161 ± 2
190 ± 4*
241 ± 2
234 ± 5
Food intake (g/24 h)
14.08 ± 0.23
14.85 ± 0.29
15.38 ± 0.53
19.29 ± 2.33
Fluid intake (mL/24 h)
19.82 ± 0.86
31.63 ± 1.38*
21.88 ± 0.69
21.86 ± 4.37
P Na+ (mmol/L)
144 ± 1
143 ± 1
135 ± 3
135 ± 1
P K+ (mmol/L)
5.50 ± 0.37
6.13 ± 0.77
5.23 ± 0.25
5.80 ± 0.30
P creatinine (mg/L)
2.84 ± 0.09
5.04 ± 0.39*
2.20 ± 0.20
3.20 ± 0.30*
P proteins (g/L)
47.84 ± 0.41
35.98 ± 3.02*
49.42 ± 1.55
48.98 ± 2.98
C creatinine (mL/min)
3.91 ± 0.39
2.25 ± 0.28*
4.51 ± 1.08
2.24 ± 0.32*
Na+ intake (mmol/24 h)
1.16 ± 0.02
1.20 ± 0.02
1.31 ± 0.05
1.57 ± 0.28
Ascites (g)
0.61 ± 0.08
14.31 ± 2.46*
0.60 ± 0.10
1.30 ± 0.30*
Na+ balance (mmol/24 h)
0.15 ± 0.06
0.89 ± 0.07*
0.18 ± 0.13
−0.61 ± 0.38*
(%)
0.32 ± 0.02
0.05 ± 0.01*
0.17 ± 0.03
0.53 ± 0.14*
U Na+ (mmol/24 h)
1.02 ± 0.06
0.32 ± 0.05*
1.13 ± 0.13
2.00 ± 0.24
U K+ (mmol/24 h)
1.30 ± 0.11
1.82 ± 0.16*
1.37 ± 0.05
1.92 ± 0.17*
U proteins (mg/24 h)
30 ± 4
298 ± 40*
38 ± 7
438 ± 47*
U creatinine (mmol/24 h)
0.046 ± 0.001
0.049 ± 0.004
0.092 ± 0.009
0.085 ± 0.009
Values are means ± SE; = 4 to 5 experiments per group. U: urinary; FE: fractional excretion; P: plasma; and C creatinine: creatinine clearance. *, significantly different from corresponding values in control rats.
