Development of Multiexon Skipping Antisense Oligonucleotide Therapy for Duchenne Muscular Dystrophy

Figure 2

Exons 45–55 skipping with a mixture of 10 vPMOs in mdx52 mouse. Mdx52 mouse lacks exon 52 in the mRNA of the murine DMD gene, leading to out-of-frame products. Exons 45–55 skipping with mixture vPMOs (black line) restores the reading frame of DMD mRNA.