In Vitro Cytotoxicity and In Vivo Acute and Chronic Toxicity of Xanthii Fructus and Its Processed Product

Figure 5

Comparison of microscopic morphology in kidney (a) and liver (b) tissue between Group I (control group), Group II (low dosage of XF), Group III (middle dosage of XF), and Group VII (high dosage of PXF). Original magnification ×200.

(a) Microscopic morphology in kidney. Group I: only mild edema was observed. Group II: mild-to-moderate tubular edema, renal interstitial inflammation, tubular exudation, and tubular necrosis were observed. Group III: mild-to-moderate tubular edema, renal interstitial inflammation, tubular exudation, and tubular necrosis were observed. Group VII: mild-to-moderate tubular edema, renal interstitial inflammation, tubular exudation, and tubular necrosis were observed

(b) Microscopic morphology in liver. Group I: mild hepatocytes edema degeneration was observed. Group II: mild-to-moderate edema degeneration, mild-to-moderate spotty necrosis, focal necrosis, and mild degree inflammation were observed. Group III: Mild-to-moderate edema degeneration, mild-to-moderate spotty necrosis, focal necrosis and mild-to-moderate degree inflammation were observed. Group VII: mild-to-severe edema degeneration, mild-to-moderate spotty necrosis and mild degree inflammation were observed