BioMed Research International / 2013 / Article / Tab 2 / Review Article
Recent Advances in Genetic Predisposition of Myasthenia Gravis Table 2 Association of PTPN22 rs2476601 and rs2488457 SNPs with distinct MG subgroups, in six different populations.
SNP/Associated allele Ethnic group or descent MG subgroup Number of cases
valueReference rs2476601/1858T North European EOMG with thymus hyperplasia 649
[19 ] French Nonthymoma & ATA (−) 293
[21 ] Nonthymoma & ATA (+) 97 NS Thymoma 80 NS Swedish Caucasian All patients 409
[20 ] Thymus hyperplasia 142
AChR (+) 350
Thymus hyperplasia & AChR (+) 128
German & Hungarian All nonthymoma MG patients 208 NS
[45 ] Nonthymoma & ATA (+) 50
Nonthymoma & ATA (−) 152 NS AChR (+) 164
0.05Thymoma 33 NS German Caucasian Thymoma 79
[46 ] EOMG —
Italian Caucasian All MG patients 356
[47 ] EOMG 117
AChR (+) 252
MuSK (+) 72
Thymoma 56
Nonthymoma 300
Meta-analysis of the [20 , 21 , 45 , 46 ] All MG patients — <1
[47 ] Nonthymoma — <1
AChR (+) — <1
Thymoma — NS rs2488457/-1123C Italian Caucasian AChR (+) with low titer
10 nM 50 0.019 [47 ]
Adjusted according to Bonferroni correction for multiple testing.
b
values were calculated based on genotype frequencies between patients and controls.