The figure shows the free-energy landscape of various TF-RE complexes (TF: pale pink; Res: blue, green, and pink/red; cofactor: purple). The binding of the cofactor causes a population shift towards a particular TF-RE complex (indicated by the arrow). As is shown, the TF complex with blue RE is the most stable prior to cofactor binding. After this event, the complex with the red RE is the most stable interaction. By the mechanism stated herein, the binding of the purple co-factor shifts the populations in favour of the TF-red RE complex [31].
