Table 1: Scale change in nonspecific digestion.

DB Version Fasta size (MB) No. of proteins No. of peptide fragments Index size (GB) ipi.HUMAN 3.87 48.71 91,491 1,939,985,477 44.44 UNIPROT-SPROT 201108 240.51 532,234 9,964,797,926 235.51

Note: peptide mass is 300–8000 Dalton. Peptide length is 3–60 amino acids.