Polyisoprenylated Methylated Protein Methyl Esterase Is Both Sensitive to Curcumin and Overexpressed in Colorectal Cancer: Implications for Chemoprevention and Treatment
Figure 5
(a) Immunohistochemical analysis of TMA cores from colon cancer cases showing brown staining for PMPMEase immunoreactivity. The TMAs were probed with PMPMEase antibodies and scored for the relative intensities of PMPMEase staining as described in the methods. Intense staining was observed in colon adenocarcinoma (stage I, B, C and D), mucinous adenocarcinomas (stage 2, F), signet ring cell carcinoma (stage II, G) and papillary adenoma (stage 2, H). A and E are images of sections obtained from normal colon tissue and normal adjacent tissue, respectively. Each image is of a section from the tumor of a separate case. (b) Magnified sections of colon adenocarcinoma (B, C and D), mucinous adenocarcinomas (F), signet ring cell carcinoma (G) and papillary adenoma (H). Areas with dense populations of blue-stained nuclei indicative of tumor cells also show a higher intensity of brown staining for PMPMEase. A and E are magnified images of sections obtained from normal colon and normal adjacent tissues, respectively.
