Role of STAT3 in Cancer Metastasis and Translational Advances

Table 2

Small molecule STAT3 inhibitors and their structure.

STAT3 inhibitor	Structure	Mechanism of inhibition
(1) Curcumin		Inhibits STAT3 activation and STAT3 DNA binding
(2) Resveratrol		Inhibition of STAT3 activation and STAT3-regulated signaling pathway
(3) Cucurbitacin derivatives	Structure of various cucurbitacin derivatives	Mechanism of inhibition
Cucurbitacin I		Inhibition of STAT3 binding to DNA and gene transcription
Cucurbitacin B		Inhibition of STAT3 activation and STAT3 binding to DNA
Cucurbitacin E		Inhibition of STAT3 activation and gene expression
Cucurbitacin Q		Inhibition of STAT3 activation without inhibition in JAK2
(4) Flavopiridol		Disrupts STAT3/DNA interactions and inhibits STAT3 gene transcription and translation
(5) Deoxytetrangomycin		Abrogates STAT3 dimerization, STAT3 nuclear translocation and STAT3 DNA binding
(6) Cyclopentenone Derivatives		Inhibits tyrosine phosphorylation of STAT3, STAT1 and serine phosphorylation of STAT3
(7) N-Acyl homoserine lactone		Inhibition of STAT3 activation
(8) Indirubin derivatives	Structure of various indirubin derivatives	Mechanism of inhibition
E804		Inhibition of STAT3 activation and STAT3 gene expression
6-Bromoindirubin-3-oxime		Inhibition of STAT3 activation and STAT3 gene expression
𝐼𝑛𝑑𝑖𝑟𝑢𝑏𝑖𝑛-3^′-𝑚𝑜𝑛𝑜𝑥𝑖𝑚𝑒		Inhibition of STAT3 activation
(9) Tyrphostin/AG490		Inhibition of STAT3 activation and STAT3-DNA binding
(10) Platinum-containing compounds and their derivatives	Structure of various platinum containing compounds	Mechanism of inhibition
Cisplatin		Dephosphorylation of JAK2/STAT3
CPA-1		Inhibition of STAT3 activation and STAT3-DNA binding
CPA-7		Inhibition of STAT3 activation and STAT3-DNA binding
(11) Atiprimod		Inhibition of STAT3 activation
(12) Pentoxifylline		Inhibition of STAT3 activation, STAT3 nuclear translocation and STAT3-DNA binding