Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2013, Article ID 427640, 10 pages
http://dx.doi.org/10.1155/2013/427640
Research Article

Chronic Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Activity Decreases Hypertension, Insulin Resistance, and Hypertriglyceridemia in Metabolic Syndrome

Heart Failure Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, UW2521, P.O. Box 1539, 709 Swedeland Road, King of Prussia, PA 19406-0939, USA

Received 5 October 2012; Accepted 18 February 2013

Academic Editor: Joseph Fomusi Ndisang

Copyright © 2013 Christine G. Schnackenberg et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [20 citations]

The following is the list of published articles that have cited the current article.

  • Daisy L. Daubert, Benjamin M. Looney, Rebekah R. Clifton, Jake N. Cho, and Deborah A. Scheuer, “Elevated corticosterone in the dorsal hindbrain increases plasma norepinephrine and neuropeptide Y, and recruits a vasopressin response to stress,” American Journal of Physiology-Regulatory Integrative and Comparative Physi, vol. 307, no. 2, pp. R212–R224, 2014. View at Publisher · View at Google Scholar
  • Gregers Wegener, “Let food be thy medicine, and medicine be thy food: Hippocrates revisited,” Acta Neuropsychiatrica, vol. 26, no. 1, pp. 1–3, 2014. View at Publisher · View at Google Scholar
  • Abdulmaged M. Traish, Andre T. Guay, and Michael Zitzmann, “5α-Reductase inhibitors alter steroid metabolism and may contribute to insulin resistance, diabetes, metabolic syndrome and vascular disease: A medical hypothesis,” Hormone Molecular Biology and Clinical Investigation, vol. 20, no. 3, pp. 73–80, 2014. View at Publisher · View at Google Scholar
  • E. Passos, C. Pereira, I.O. Gonçalves, S. Rocha-Rodrigues, N. Silva, J.T. Guimarães, D. Neves, A. Ascensão, J. Magalhães, and M.J. Martins, “Role of physical exercise on hepatic insulin, glucocorticoid and inflammatory signaling pathways in an animal model of non-alcoholic steatohepatitis,” Life Sciences, 2014. View at Publisher · View at Google Scholar
  • Rachel K. Crowley, Beverly Hughes, Joanna Gray, Theresa McCarthy, Susan Hughes, Cedric H. L. Shackleton, Nicola Crabtree, Peter Nightingale, Paul M. Stewart, and Jeremy W. Tomlinson, “Longitudinal changes in glucocorticoid metabolism are associated with later development of adverse metabolic phenotype,” European Journal of Endocrinology, vol. 171, no. 4, pp. 433–442, 2014. View at Publisher · View at Google Scholar
  • Peter Slezak, Angelika Puzserova, Peter Balis, Natalia Sestakova, Miroslava Majzunova, Ima Dovinova, Michal Kluknavsky, and Iveta Bernatova, “Genotype-Related Effect of Crowding Stress on Blood Pressure and Vascular Function in Young Female Rats,” BioMed Research International, vol. 2014, pp. 1–11, 2014. View at Publisher · View at Google Scholar
  • Daniela Melis, Alessandro Rossi, Rosario Pivonello, Mariacarolina Salerno, Francesca Balivo, Simona Spadarella, Giovanna Muscogiuri, Roberto Della Casa, Pietro Formisano, Generoso Andria, Annamaria Colao, and Giancarlo Parenti, “Glycogen storage disease type Ia (GSDIa) but not Glycogen storage disease type Ib (GSDIb) is associated to an increased risk of metabolic syndrome: possible role of microsomal glucose 6-phosphate accumulation,” Orphanet Journal of Rare Diseases, vol. 10, no. 1, 2015. View at Publisher · View at Google Scholar
  • Houda Zoubiri, Ghouti Kacimi, El Mahdi Haffaf, Brahim Oudjit, Naima Adjroud, and Elhadj-Ahmed Koceir, “Cardiometabolic and cardiorenal syndromes interactions in Algerian diabetic-hypertensive patient: interest of predictive multi-biomarkers strategy to ,” Annales De Biologie Clinique, vol. 73, no. 4, pp. 443–453, 2015. View at Publisher · View at Google Scholar
  • Piers R. Blackett, Don P. Wilson, and Catherine McNeal, “Secondary hypertriglyceridemia in children and adolescents,” Journal of Clinical Lipidology, 2015. View at Publisher · View at Google Scholar
  • Ludovit Paulis, Romana Rajkovicova, and Fedor Simko, “New Developments in the Pharmacological Treatment of Hypertension: Dead-End or a Glimmer at the Horizon?,” Current Hypertension Reports, vol. 17, no. 6, 2015. View at Publisher · View at Google Scholar
  • Maria-José Barahona, Elena Valassi, and Susan M. Webb, “Adrenal Gland Hormones and the Vascular System,” PanVascular Medicine, pp. 4641–4651, 2015. View at Publisher · View at Google Scholar
  • Maria-José Barahona, and Susan M. Webbpp. 4641–4651, 2015. View at Publisher · View at Google Scholar
  • Mathurin Fumery, Benjamin Pariente, Helene Sarter, Cloé Charpentier, Laura Armengol Debeir, Jean-Louis Dupas, Hugues Coevoet, Laurent Peyrin-Biroulet, Laurence dʼAgay, Corinne Gower-Rousseau, and Guillaume Savoye, “Natural History of Crohnʼs Disease in Elderly Patients Diagnosed Over the Age of 70 Years,” Inflammatory Bowel Diseases, vol. 22, no. 7, pp. 1698–1707, 2016. View at Publisher · View at Google Scholar
  • Michael H. Smolensky, Ramón C. Hermida, and Francesco Portaluppi, “Circadian mechanisms of 24-hour blood pressure regulation and patterning,” Sleep Medicine Reviews, 2016. View at Publisher · View at Google Scholar
  • M. Akhtar Anwar, Alaaeldin I. Saleh, Reem Al Olabi, Tuqa S. Al Shehabi, and Ali H. Eid, “Glucocorticoid-induced fetal origins of adult hypertension: Association with epigenetic events,” Vascular Pharmacology, 2016. View at Publisher · View at Google Scholar
  • André J. Scheen, “Cibler la voie métabolique du cortisol comme action thérapeutique dans le diabète de type 2,” Médecine des Maladies Métaboliques, vol. 10, no. 8, pp. 725–731, 2016. View at Publisher · View at Google Scholar
  • Li Linyi, Hisae Yoshitomi, Qin Lingling, Wu Xinli, Zhou Tian, Wang Haiyan, Jiang Yueying, Wei Ying, Xu Tunhai, Liu Tonghua, and Gao Ming, “Tangnaikang improves insulin resistance and β-cell apoptosis by ameliorating metabolic inflammation in SHR.Cg-Lepr cp /NDmcr rats,” Journal of Traditional Chinese Medicine, vol. 37, no. 3, pp. 361–370, 2017. View at Publisher · View at Google Scholar
  • Aleid J. G. Wirix, Ines A von Rosenstiel-Jadoul, Jeroen Nauta, Jaap W Groothoff, Mai J. M. Chinapaw, Joana E Kist-van Holthe, Martijn J. J. Finken, and Annemieke C Heijboer, “Is there an association between cortisol and hypertension in overweight or obese children?,” JCRPE Journal of Clinical Research in Pediatric Endocrinology, vol. 9, no. 4, pp. 344–349, 2017. View at Publisher · View at Google Scholar
  • Matthew A. Bailey, “11β-Hydroxysteroid Dehydrogenases and Hypertension in the Metabolic Syndrome,” Current Hypertension Reports, vol. 19, no. 12, 2017. View at Publisher · View at Google Scholar
  • Antonio Sircana, Franco De Michieli, Renato Parente, Luciana Framarin, Nicola Leone, Mara Berrutti, Elena Paschetta, Daria Bongiovanni, and Giovanni Musso, “Gut Microbiota, Hypertension and Chronic kidney Disease: recent advances,” Pharmacological Research, 2018. View at Publisher · View at Google Scholar