Human Induced Pluripotent Stem Cells from Basic Research to Potential Clinical Applications in Cancer

Table 3

Summary of cancer-derived hiPSCs.

Type of cancer (hematologic malignancies and solid tumors)	Aim of study	Method of generation of the cancer hiPSCs	References
Myeloproliferative disorder (MPD) with JAK2-V617F somatic mutation	To generate iPS cells to provide a renewable cell source and a prospective hematopoiesis model for investigating MPD pathogenesis	Frozen peripheral blood CD34^+ cells from 2 patients with MPD/retroviral transduction	Ye et al., 2009 [55]
Chronic myeloid leukemia (CML)	To address whether human cancer cells can be reprogrammed into iPSCs	Cell line, KBM7, derived from blast crisis stage of CML/retroviral transduction	Carette et al., 2010 [56]
Chronic myeloid leukemia (CML)	To eliminate the genomic integration and background transgene expression, toward advancing iPSCs technology for the modeling of blood diseases	Bone marrow mononuclear cells from a patient with CML (chronic phase)/episomal vectors	Hu et al., 2011 [57]
Chronic myeloid leukemia (CML)	To investigate CML pathogenesis on the basis of patient-derived samples	Two patients samples of CML (chronic phase) bone marrow cells, retrovirus and Sendai virus system	Kumano et al., 2012 [19]
Juvenile myelomonocytic leukemia (JMML)	To explore the pathophysiology and treatment of JMML	Two pediatric patient’s samples from bone marrow or peripheral blood/lentivirus	Gandre-Babbe et al., 2013 [61]
Gastrointestinal cancer	To study new cancer therapies via reprogramming approaches in cancer cells	Gastrointestinal cell lines of cancers from esophageal, stomach, colorectal, pancreas, and liver and bile ducts/lentiviral and retroviral	Miyoshi et al., 2010 [58]
Gastrointestinal cancer	Generate a human cell model of early pancreatic cancer and disease progression for biomarkers detection for useful diagnosis	Tissue from the center of pancreatic ductal adenocarcinoma (PDAC) sample of patient/lentivirus system	Kim et al., 2013 [59]