The Protective Effect of Fasudil on the Structure and Function of Cardiac Mitochondria from Rats with Type 2 Diabetes Induced by Streptozotocin with a High-Fat Diet Is Mediated by the Attenuation of Oxidative Stress
Effect of fasudil on transmembrane potential in mitochondria. Red fluorescence represents the mitochondrial aggregate form of JC-1 (JC-1 polymers), which indicates the intact mitochondrial membrane potential. Green fluorescence represents the monomeric form of JC-1 (JC-1 monomers), which indicates the dissipation of mitochondrial transmembrane potential. (a) Representative results of cardiac mitochondria stained with JC-1 and derived from fasudil-treated, untreated diabetic, and control rats. (b) Ratios of JC-1 monomer to JC-1 polymer (red/green fluorescence) for untreated diabetic rats, diabetic rats treated with fasudil, and control rats. Data are expressed as the mean ± SD. The ratio was significantly lower for diabetic rats treated with fasudil than for untreated diabetic rats ().