Research Article

Transcriptional Response of Bovine Monocyte-Derived Macrophages after the Infection with Different Argentinean Mycobacterium bovis Isolates

Table 3

Genes upregulated in PBMCs of M. bovis infected and control cells.

Probeset IDGene symbolGene entrez IDGene nameLog FC*FC value value

Probesets differentially expressed in 303 infected versus control (cut-off: 0.05)

Bt.28345.1.S1_atANKRD17508405Ankyrin repeat domain 171,4562,7436,628 0,032783
Bt.234.1.S1_atIL18281249Interleukin 18 (interferon-gamma-inducing factor)1,4402,7147,235 0,033570
Bt.23611.3.S1_atTIPARP540975TCDD-inducible poly(ADP-ribose) polymerase1,3402,5311,245 0,042252

Probesets differentially expressed in 303 infected versus control and 534 infected versus control (cut-off: 0.05)

Bt.19496.1.A1_at ND** ND ND2,7536,7433,035 0,000141
Bt.23911.1.A1_atXIST338325X (inactive)-specific transcript2,6036,0781,270 0,000295
Bt.28320.1.A1_at ND ND ND2,5285,7692,532 0,000392
Bt.6566.2.S1_a_at ND ND ND2,2794,8542,194 0,002512
Bt.647.1.S1_atMTPN541099Myotrophin2,1944,5754,399 0,002707
Bt.11778.1.A1_at ND ND ND2,1784,5264,974 0,002707
Bt.18321.1.A1_atGNB4525962Guanine nucleotide binding protein (G protein), beta polypeptide 42,1584,4645,823 0,002707
Bt.23678.1.A1_atRQCD1536537RCD1 required for cell differentiation1 homolog (S. pombe)2,1584,4635,834 0,002707
Bt.12745.3.S1_atANTXR2510080Anthrax toxin receptor 22,0934,2669,681 0,004084
Bt.2096.2.S1_atEHD4505206EH domain containing 42,0704,2001,150 0,004446

Probesets differentially expressed in 534 infected versus control (cut-off: 0.05)

Bt.24940.1.A1_at ND ND ND2,7626,7842,698 1,043
Bt.5395.1.S1_a_atVCAN282662Versican2,1164,3363,182 2,636
Bt.24975.1.S1_atYTHDC2541024YTH domain containing 22,0374,1045,290 3,880

FC: fold change; **ND: not defined.