Characterization of Schizophrenia Adverse Drug Interactions through a Network Approach and Drug Classification
Table 2
Comparison of drugs belonging to the “nervous Systems” category with drugs from the other categories based on their degrees in human adverse drug-drug interaction network.
ATC first-level classification (ATC code)
Number of drugs
Average degree
Wilcoxon test -value
Bonferroni adjusted -value
Antineoplastic and immunomodulating agents (L)
118
15.25
Various (V)
22
7.14
Alimentary tract and metabolism (A)
119
15.52
Blood and blood forming organs (B)
45
21.00
0.0042
Sensory organs (S)
85
19.66
0.0089
0.1242
Respiratory system (R)
75
20.27
0.0148
0.2068
Antiinfectives for systemic use (J)
143
25.19
0.0228
0.3186
Musculoskeletal system (M)
56
14.39
0.0287
0.4021
Cardiovascular system (C)
153
22.75
0.7008
1.000
Dermatologicals (D)
56
25.27
0.4775
1.000
Genitourinary system and sex hormones (G)
61
21.38
0.1570
1.000
Systemic hormonal preparations, excluding sex hormones and insulins (H)
21
20.76
0.5294
1.000
Antiparasitic products, insecticides, and repellents (P)
