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BioMed Research International
Volume 2013 (2013), Article ID 459168, 7 pages
Clinical Study

Aorta Structural Alterations in Term Neonates: The Role of Birth and Maternal Characteristics

1Cardiovascular Disease Section, Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124 Bari, Italy
2Dipartimento di Medicina Traslazionale-Laboratorio Igiene ed Medicina Ambientale, University of Piemonte Orientale A. Avogadro, Via Duomo 6, 13100 Vercelli, Italy
3Department of Cardiovascular Disease Rehabilitation, U.S.L.2, Via Guerra 21, 06127 Perugia, Italy
4Neonatology and Neonatal Intensive Care Section, Department of Gynecology, Obstetrics and Neonatology, University of Bari, Piazza G. Cesare 11, 70124 Bari, Italy

Received 5 April 2013; Revised 28 June 2013; Accepted 8 July 2013

Academic Editor: Egle Bytautiene

Copyright © 2013 Marco Matteo Ciccone et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. To evaluate the influence of selected maternal and neonatal characteristics on aorta walls in term, appropriately grown-for-gestational age newborns. Methods. Age, parity, previous abortions, weight, height, body mass index before and after delivery, smoking, and history of hypertension, of diabetes, of cardiovascular diseases, and of dyslipidemia were all assessed in seventy mothers. They delivered 34 males and 36 females healthy term newborns who underwent ultrasound evaluation of the anteroposterior infrarenal abdominal aorta diameter (APAO), biochemical profile (glucose, insulin, total cholesterol, HDL and LDL cholesterol, triglycerides, fibrinogen, and D-dimers homeostasis model assessment [HOMAIR]index), and biometric parameters. Results. APAO was related to newborn length ( ; ), head circumference ( ; ), gestational age ( , ), HOMA index ( ; ), and D-dimers ( , ). Smoke influenced APAO values (odds ratio: 1.80; confidence interval 95%: 1.05–3.30), as well as diabetes during pregnancy ( , ). Maternal height influenced neonatal APAO ( , ). Multiple regression analysis outlined neonatal D-dimers as still significantly related to neonatal APAO values. Conclusions. Many maternal and neonatal characteristics could influence aorta structures. Neonatal D-dimers are independently related to APAO.