Clinical Study
Role of Toll-Interacting Protein Gene Polymorphisms in Leprosy Mexican Patients
Table 2
Genotype and allele distributions of −526, exon 4, exon 6, and 3′UTR TOLLIP polymorphisms in LL and HS.
| | Polymorphism | LL ()
n (%) | HS ()
n (%) | OR CI (95%) | value |
| | rs5743854 | | | | | | (−526 C>G) | | | | | | Genotype | | | | | | C/C | 84 (86) | 127 (84) | | | | C/G | 13 (13) | 22 (14) | 0.89 (0.43–1.87) | | | G/G | 1 (1) | 3 (2) | 0.50 (0.05–4.93) | | | Allele | | | | | | C | 181 (92) | 276 (91) | | | | G | 15 (8) | 28 (9) | 0.82 (0.42–0.16) | | | HWE = 0.43 | | | | | | rs3750920 | | | | | | (1309956 C>T) | | | | | | Genotype | | | | | | C/C | 24 (25) | 56 (37) | | | | C/T | 63 (64) | 83 (54) | 1.77 (0.99–3.16) | | | T/T | 11 (11) | 13 (9) | 1.97 (0.772–5.02) | | | Allele | | | | | | C | 111 (57) | 195 (64) | | | | T | 85 (43) | 109 (36) | 1.37 (0.95–1.98) | | | HWE = 0.04 | | | | | | rs5744015 | | | | | | (1298430 C>A) | | | | | | Genotype | | | | | | C/C | 96 (98) | 148 (97) | | | | C/A | 2 (2) | 4 (3) | 0.80 (0.14–4.29) | | | A/A | 0 (0) | 0 (0) | 1.54 (0.03–78.2) | | | Allele | | | | | | C | 194 (99) | 300 (99) | | | | A | 2 (1) | 4 (1) | 0.77 (0.14–4.26) | | | HWE = 1.00 | | | | | | rs3750919 | | | | | | (1292831 G>A) | | | | | | Genotype | | | | | | G/G | 48 (49) | 81 (53) | | | | G/A | 40 (41) | 62 (41) | 1.09 (0.64–1.86) | | | A/A | 10 (10) | 9 (6) | 1.87 (0.71–4.94) | | | Allele | | | | | | G | 136 (69) | 224 (74) | | | | A | 60 (31) | 80 (26) | 1.24 (0.83–1.84) | | | HWE = 0.81 | | | | |
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LL: lepromatous leprosy; HS: healthy subjects; OR: odds ratio; C: confidence interval; HWE: Hardy-Weinberg equilibrium value; codominant model is presented.
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