Research Article
Prolonged Delivery of Ciprofloxacin and Diclofenac Sodium from a Polymeric Fibre Device for the Treatment of Peridontal Disease
Table 4
MIC results for ciprofloxacin/diclofenac-loaded fibres from dissolution samples in PBS pH 4.0 and 6.8 over 10 days.
| Dissolution samples | PBS pH 4.0 | PBS pH 6.8 | E. coli | E. faecalis | S. mutans | E. coli | E. faecalis | S. mutans |
| Day 1 | 0.5 | 0.4 | 0.7 | 0.4 | 0.4 | 0.8 | Day 2 | 0.6 | 0.6 | 1.2 | 0.5 | 0.5 | 1.0 | Day 4 | 0.7 | 1.1 | 1.4 | 0.4 | 0.4 | 0.8 | Day 6 | 0.8 | 0.8 | 1.7 | 0.3 | 0.3 | 0.6 | Day 8 | 0.5 | 0.4 | 1.9 | 0.5 | 0.5 | 0.9 | Day 10 | 0.5 | 0.5 | 2.1 | 0.5 | 0.5 | 1.0 |
| Controls | | | | | | | Ciprofloxacin | 2.5 | 2.5 | 10.0 | 2.5 | 2.5 | 10.0 | Diclofenac | NI | NI | NI | NI | NI | NI | Drug free fibres (Day 1–10) | NI | NI | NI | NI | NI | NI | PBS pH 4.0 | NI | NI | NI | NI | NI | NI | Broth with culture | NI | NI | NI | NI | NI | NI | Broth | NG | NG | NG | NG | NG | NG |
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NI: no inhibition; NG: no growth. All values are expressed as g/mL.
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