Evidence for the Treatment of Osteoporosis with Vitamin D in Residential Care and in the Community Dwelling Elderly
Table 5
Results of community and residential studies measuring BMD.
Sample size
Regimen
Maximum followup
Sites
BMD change versus baseline (%)
Active
Comparator
P
Chapuy
56
CaD versus P
18 months
Femoral neck Total proximal femur Trochanter Intertrochanteric
0.036 <0.001 0.044 NS
Decalyos II
114
CaD versus P
2 years
Femoral neck Distal radius*
NS
583
NA
NA
NS
Zhu
302
CaD versus CaP
1 year
Total body Total hip
NS NS
Kyphos
120
CaD versus P
5 years
Total hip
0.05
Ooms
348
D versus P
2 years
L femoral neck R femoral neck L femoral trochanter R femoral trochanter Distal radius
+1.6 +1.2 −1.1 −0.9 −2.7
−0.3 −1.4 −0.9 −0.9 −2.4
0.01 0.001 NS NS NS
Values are mean ± standard deviation; NS: not significant; CaD: calcium and vitamin D; P: placebo or control; NA: not available. *Single X-ray absorptiometry.
