Effects of an Agaricus blazei Aqueous Extract Pretreatment on Paracetamol-Induced Brain and Liver Injury in Rats

Table 4

Effects of paracetamol injury and A. blazei pretreatment on antioxidant enzyme activities in the liver and brain tissues. For experimental details see Section 2.

Enzymes	Organ	I, control	II, A. blazei pretreatment	III, paracetamol injury	IV, A. blazei pretreatment + paracetamol injury
Catalase (μmol min^−1 mg^−1)	Liver	1078.8 ± 75.1 (𝑛=4)	942.5 ± 104.1 (𝑛=3)	597.0 ± 68.2 (𝑛=4)^a,b,c	898.3 ± 33.9 (𝑛=4)
	Brain	15.97 ± 0.79 (𝑛=5)	16.79 ± 1.21 (𝑛=5)	12.00 ± 0.98 (𝑛=6)^a,b	14.56 ± 0.77 (𝑛=5)
Superoxide dismutase (units mg^−1)	Liver	4.29 ± 0.14 (𝑛=4)	4.3 ± 0.42 (𝑛=4)	2.97 ± 0.17 (𝑛=4)^a,b	3.30 ± 0.22 (𝑛=4)^d,e
	Brain	2.03 ± 0.13 (𝑛=5)	1.97 ± 0.09 (𝑛=5)	1.46 ± 0.09 (𝑛=6)^a,b,c	1.78 ± 0.10 (𝑛=7)
Glutathione reductase (nmol min^−1 mg^−1)	Liver	36.11 ± 3.11 (𝑛=4)	38.38 ± 2.04 (𝑛=4)	46.25 ± 5.85 (𝑛=3)	47.25 ± 1.82 (𝑛=3)
	Brain	14.34 ± 0.73 (𝑛=6)	15.58 ± 0.99 (𝑛=6)	12.76 ± 0.43 (𝑛=8)^b,c	14.99 ± 0.44 (𝑛=8)
Glutathione peroxidase (nmol min^−1 mg^−1)	Liver	107.2 ± 5.7 (𝑛=3)	133.8 ± 9.0 (𝑛=3)	122.3 ± 16.2 (𝑛=3)	139.7 ± 16.1 (𝑛=3)
	Brain	33.0 ± 1.3 (𝑛=5)	31.5 ± 2.1 (𝑛=5)	27.4 ± 0.5 (𝑛=6)^a	30.8 ± 0.7 (𝑛=7)

Significant differences (𝑃≤0.05), according to one-way ANOVA followed by Student-Newman-Keuls post-hoc testing, are identified by the superscript letters as follows: ^aIII versus I; ^bIII versus II; ^cIII versus IV; ^dIV versus I; ^eIV versus II.