Research Article

Modulation of the Effects of Lung Immune Response on Bone Marrow by Oral Antigen Exposure

Figure 1

Effects of oral tolerization on eosinopoiesis and anti-OVA antibody. BP-2 mice, orally preexposed to OVA and further subcutaneously sensitized/boosted with OVA, were either saline challenged (OVA/OVA/SAL) or OVA challenged (OVA/OVA/OVA) by the intranasal route. Controls were given water, sensitized/boosted, and either saline challenged (H2O/OVA/SAL) or OVA challenged (H2O/OVA/OVA). Bone marrow ((a), (b)) and plasma ((c), (d)) were collected 24 h after-challenge. Data are Mean ± SEM. (a) EPO+ cell numbers in freshly collected BM ( ) (* for the indicated differences). (b) EPO+ cell numbers in bone marrow cultured with the indicated concentrations of IL-5 for 7 days. ( ) (* for the indicated differences relative to the respective control groups). ((c), (d)) Titration curves for IgG (c) and IgE (d) anti-OVA antibodies ( ) (* for the differences relative to the respective control groups).
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(c)
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(d)