Improvement of Daptomycin Production in Streptomyces roseosporus through the Acquisition of Pleuromutilin Resistance

Table 3

Daptomycin phenotypes and genotypes of rplC mutants.

Strain	Daptomycin phenotype	Codon 455 sequence	Corresponding Amino acid	Amino acid change
ploxp	Wild type	GGT	Glycine	None
PL, L2H, and PL11	Daptomycin overproducer	GTT	Valine	G152V
LDR, M234*	Daptomycin overproducer	GGT	Glycine	None

 *Mutation site uncharacterized.