Hydrogen Bond Acceptors and Additional Cationic Charges in Methylene Blue Derivatives: Photophysics and Antimicrobial Efficiency

<table>Synthesis of the second set of methylene blue derivatives as chloride salts (<b>4</b>–<b>6</b>); conditions: (a) DCM, secondary amine: 2-(N-methylamino)ethanol, morpholin or 4-N-methyl-piperazine, RT, 5 h; (b) ion exchanger Amberlite IRA958, water, then HCl.</table>

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Scheme 3

Scheme 3: Hydrogen Bond Acceptors and Additional Cationic Charges in Methylene Blue Derivatives: Photophysics and Antimicrobial Efficiency 