NRAMP1, VDR, HLA-DRB1, and HLA-DQB1 Gene Polymorphisms in Susceptibility to Tuberculosis among the Chinese Kazakh Population: A Case-Control Study
Table 4
Genotype and allele frequency distribution of NRAMP1 and VDR genes in the controls and TB patients of the Chinese Kazak population.
Genotype and allele
Tuberculosis (Freq)
Control (Freq)
OR (95% CI)
NRAMP1-3′UTR
TGTG++
138 (64.8)
167 (79.1)
1.00
TGTG+/del
63 (29.6)
41 (19.5)
12.802
1.859 (1.182–2.926)
0.002
TGTGdel/del
12 (5.6)
3 (1.4)
4.841 (1.339–17.499)
Alleles
TGTG
339 (79.6)
375 (88.9)
13.737
2.048 (1.395–3.006)
<0.001
TGTGdel
87 (20.4)
47 (11.1)
VDR-FokI
FF
72 (33.8)
101 (47.9)
1.00
Ff
96 (45.1)
88 (41.7)
13.095
1.530 (1.007–2.325)
0.001
ff
45 (21.1)
22 (10.4)
2.869 (1.586–5.191)
Alleles
F
240 (56.3)
290 (68.7)
13.868
1.703 (1.285–2.255)
<0.001
f
186 (43.7)
132 (31.3)
VDR-TaqI
TT
191 (89.7)
183 (86.7)
1.00
Tt
19 (8.9)
23 (10.9)
—
0.791 (0.417–1.502)
0.581
tt
3 (1.4)
5 (2.4)
0.575 (0.135–2.440)
Alleles
T
401 (94.1)
389 (92.2)
1.267
0.735 (0.429–1.259)
0.260
t
25 (5.9)
33 (7.8)
Note: Genotype frequencies were compared between the patients and control subjects by test or Fisher’s exact test when appropriate. Allele frequencies were compared between the patients and control subjects by use of a test for 2-by-2 contingency tables. : the sample size; OR: odds ratio; 95% CI: 95% confidence interval; Freq: frequency.
