Figure 4: Effect of i.p. sodium bicarbonate administration on MMP activity-related fluorescence in mouse xenografts. MMP activity in tumor bearing mice expressed as a percentage of the fluorescence taken prior to injecting 1 mL of 1 M sodium bicarbonate ( ) or PBS ( ). The mean change in fluorescence 1 hour after injection of sodium bicarbonate was statistically significant (* ). (b) Representative images comparing a PBS-treated mouse to a sodium bicarbonate-treated mouse.