BioMed Research International / 2013 / Article / Tab 1

Research Article

Liposomes-in-Hydrogel Delivery System with Mupirocin: In Vitro Antibiofilm Studies and In Vivo Evaluation in Mice Burn Model

Table 1

Quantification of antibacterial and antibiofilm activity of mupirocin samples.

Sample Biofilm bacteria
IC50, μM
(95% confidence intervals)
Planktonic bacteria
IC50, μM
(95% confidence intervals) 
Prior to biofilm formationAfter biofilm formation Turbidity

Mupirocin0.27 (0.48–0.70)50%a0.20 (0.42–0.67)
Mupirocin-in-liposomes0.58 (0.16–0.45)50%a0.53 (0.14–0.26)
Penicillin G0.13 (0.12–0.14)45.2%b0.10 (0.08–0.13)

Percentual inhibition at 405 μM.
bPercentual inhibition at 5 mM. Penicillin G fails to cause more than 45.2% of inhibition of biofilms viability in the postexposure assay, as previously shown in Skogman et al. [14].

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